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Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

  1. Author:
    Harris, L. D.
    Tabb, B.
    Sodora, D. L.
    Paiardini, M.
    Klatt, N. R.
    Douek, D. C.
    Silvestri, G.
    Muller-Trutwin, M.
    Vasile-Pandrea, I.
    Apetrei, C.
    Hirsch, V.
    Lifson, J.
    Brenchley, J. M.
    Estes, J. D.

  2. Author Address

    [Lifson, Jeffrey; Estes, Jacob D.] NCI, AIDS & Canc Virus Program, SAIC Frederick Inc, Frederick, MD 20892 USA. [Harris, Levelle D.; Klatt, Nichole R.; Hirsch, Vanessa; Brenchley, Jason M.] NIAID, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA. [Tabb, Brian] NCI, Lab Anim Sci Program, SAIC Frederick Inc, Frederick, MD 21701 USA. [Sodora, Donald L.] Seattle BioMed, Seattle, WA USA. [Paiardini, Mirko; Silvestri, Guido] Univ Penn, Dept Pathol, Philadelphia, PA 19104 USA. [Paiardini, Mirko; Silvestri, Guido] Univ Penn, Lab Med, Philadelphia, PA 19104 USA. [Douek, Daniel C.] NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Mueller-Trutwin, Michaela] Inst Pasteur, Paris, France. [Vasile-Pandrea, Ivona; Apetrei, Cristian] Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA USA.;Estes, JD, NCI, AIDS & Canc Virus Program, SAIC Frederick Inc, Frederick, MD 20892 USA.;estesj@mail.nih.gov
    1. Year: 2010
    2. Date: Aug
  2. Journal: Journal of Virology
    1. 84
    2. 15
    3. Pages: 7886-7891
  4. Type of Article: Article
  5. ISSN: 0022-538X
  1. Abstract:

    The mechanisms underlying the AIDS resistance of natural hosts for simian immunodeficiency virus (SIV) remain unknown. Recently, it was proposed that natural SIV hosts avoid disease because their plasmacytoid dendritic cells (pDCs) are intrinsically unable to produce alpha interferon (IFN-alpha) in response to SIV RNA stimulation. However, here we show that (i) acute SIV infections of natural hosts are associated with a rapid and robust type I IFN response in vivo, (ii) pDCs are the principal in vivo producers of IFN-alpha/beta at peak acute infection in lymphatic tissues, and (iii) natural SIV hosts downregulate these responses in early chronic infection. In contrast, persistently high type I IFN responses are observed during pathogenic SIV infection of rhesus macaques.

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External Sources

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  2. DOI: 10.1128/jvi.02612-09
  3. View record in Web of Science®
  4. WOS: 000279989800046

Library Notes

  1. Fiscal Year: FY2009-2010
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