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Characterization of the HPV-specific memory B cell and systemic antibody responses in women receiving an unadjuvanted HPV16 L1 VLP vaccine

  1. Author:
    Dauner, J. G.
    Pan, Y. J.
    Hildesheim, A.
    Harro, C.
    Pinto, L. A.

  2. Author Address

    [Dauner, Joseph G.; Pan, Yuanji; Pinto, Ligia A.] NCI, HPV Immunol Lab, SAIC Frederick Inc, Frederick, MD 21702 USA. [Hildesheim, Allan] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. [Harro, Clayton] Johns Hopkins Univ, Ctr Immunizat Res, Baltimore, MD 21205 USA.;Pinto, LA, NCI, HPV Immunol Lab, SAIC Frederick Inc, Bldg 469,Room 202, Frederick, MD 21702 USA.
    1. Year: 2010
    2. Date: Jul
    3. Epub Date: 7/2/2010
  2. Journal: Vaccine
    1. 28
    2. 33
    3. Pages: 5407-5413
  4. Type of Article: Article
  5. ISSN: 0264-410X
  1. Abstract:

    Human papillomavirus (HPV)-specific antibodies are proposed to be the correlate of protection afforded by HPV L1 virus-like particle (VLP) vaccines Previous studies have characterized the systemic antibody response to immunization in terms of both the quantity and the ability to neutralize HPV Here, we have adapted a generalized memory B cell ELISPOT to the HPV16 system and expanded the analysis of the systemic antibody response to include an avidity measurement of HPV 1.1 VIP-specific antibodies We show the results of the memory B cell ELISPOT significantly correlated with IgG and neutralizing antibody titers, but not with the avidity measurement This is the first comprehensive study to correlate a variety of humoral aspects potentially associated with protective immunity following vaccination with a HPV16 L1 VLP vaccine. (C) 2010 Elsevier Ltd. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.vaccine.2010.06.018
  3. PMID: 20591543
  4. PMCID: PMC2913111
  5. View record in Web of Science®
  6. WOS: 000281002200004
  7. NIHMSID: Nihms218186

Library Notes

  1. Fiscal Year: FY2009-2010
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