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Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)

  1. Author:
    Jacobs, E. J.
    Chanock, S. J.
    Fuchs, C. S.
    LaCroix, A.
    McWilliams, R. R.
    Steplowski, E.
    Stolzenberg-Solomon, R. Z.
    Arslan, A. A.
    Bueno-de-Mesquita, H. B.
    Gross, M.
    Helzlsouer, K.
    Petersen, G.
    Zheng, W.
    Agalliu, I.
    Allen, N. E.
    Amundadottir, L.
    Boutron-Ruault, M. C.
    Buring, J. E.
    Canzian, F.
    Clipp, S.
    Dorronsoro, M.
    Gaziano, J. M.
    Giovannucci, E. L.
    Hankinson, S. E.
    Hartge, P.
    Hoover, R. N.
    Hunter, D. J.
    Jacobs, K. B.
    Jenab, M.
    Kraft, P.
    Kooperberg, C.
    Lynch, S. M.
    Sund, M.
    Mendelsohn, J. B.
    Mouw, T.
    Newton, C. C.
    Overvad, K.
    Palli, D.
    Peeters, P. H. M.
    Rajkovic, A.
    Shu, X. O.
    Thomas, G.
    Tobias, G. S.
    Trichopoulos, D.
    Virtamo, J.
    Wactawski-Wende, J.
    Wolpin, B. M.
    Yu, K.
    Zeleniuch-Jacquotte, A.

  2. Author Address

    [Jacobs, Eric J.; Newton, Christina C.] Amer Canc Soc, Dept Epidemiol, Atlanta, GA 30329 USA. [Chanock, Stephen J.; Amundadottir, Laufey] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Fuchs, Charles S.; Wolpin, Brian M.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Fuchs, Charles S.; Giovannucci, Edward L.; Hankinson, Susan E.; Hunter, David J.; Wolpin, Brian M.] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA. [Buring, Julie E.] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA USA. [LaCroix, Andrea; Kooperberg, Charles] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA. [McWilliams, Robert R.] Mayo Clin, Coll Med, Dept Oncol, Rochester, MN USA. [Steplowski, Emily] Informat Management Serv Inc, Silver Spring, MD USA. [Arslan, Alan A.] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA. [Arslan, Alan A.; Zeleniuch-Jacquotte, Anne] NYU, Sch Med, Dept Environm Med, New York, NY USA. [Arslan, Alan A.; Zeleniuch-Jacquotte, Anne] NYU, Inst Canc, New York, NY USA. [Bueno-de-Mesquita, H. Bas] Natl Inst Publ Hlth & Environm, RIVM, NL-3720 BA Bilthoven, Netherlands. [Bueno-de-Mesquita, H. Bas] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands. [Gross, Myron] Univ Minnesota, Sch Med, Dept Lab Med Pathol, Minneapolis, MN 55455 USA. [Helzlsouer, Kathy] Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA. [Petersen, Gloria] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA. [Zheng, Wei; Shu, Xiao-Ou] Vanderbilt Univ, Dept Med, Vanderbilt Ingram Canc Ctr, Nashville, TN USA. [Agalliu, Ilir] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA. [Allen, Naomi E.] Univ Oxford, Canc Epidemiol Unit, Oxford, England. [Boutron-Ruault, Marie-Christine] INSERM, F-75654 Paris 13, France. [Boutron-Ruault, Marie-Christine] Inst Gustave Roussy, Villejuif, France. [Buring, Julie E.] Brigham & Womens Hosp, Dept Med, Div Prevent Med & Aging, Boston, MA 02115 USA. [Buring, Julie E.] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA. [Canzian, Federico] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany. [Clipp, Sandra] George W Comstock Ctr Publ Hlth Res & Prevent, Hagerstown, MD USA. [Gaziano, J. Michael] Brigham & Womens Hosp, Dept Med, Phys Hlth Study, Div Aging Cardiovasc Dis & Prevent Med, Boston, MA 02115 USA. [Gaziano, J. Michael] Vet Affairs Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA. [Giovannucci, Edward L.] Harvard Univ, Sch Med, Dept Nutr, Boston, MA USA. [Giovannucci, Edward L.; Hankinson, Susan E.; Hunter, David J.; Kraft, Peter; Trichopoulos, Dimitrios] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Jacobs, Kevin B.] BioInformed LLC, Gaithersburg, MD USA. [Jacobs, Kevin B.] NCI, Core Genotyping Facil, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21701 USA. [Jenab, Mazda] Int Agcy Res Canc, F-69372 Lyon, France. [Lynch, Shannon M.] NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA. [Sund, Malin] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden. [Mouw, Tracy; Peeters, Petra H. M.] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England. [Overvad, Kim] Aarhus Univ Hosp, Dept Cardiol, Aalborg Hosp, Aalborg, Denmark. [Overvad, Kim] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg Hosp, Aalborg, Denmark. [Palli, Domenico] Canc Res & Prevent Inst ISPO Florence, Mol & Nutr Epidemiol Unit, Florence, Italy. [Peeters, Petra H. M.] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [Rajkovic, Aleksandar] Univ Pittsburgh, Dept Obstet & Gynecol, Pittsburgh, PA USA. [Trichopoulos, Dimitrios] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece. [Virtamo, Jarmo] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland. [Wactawski-Wende, Jean] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.;Jacobs, EJ, Amer Canc Soc, Dept Epidemiol, Atlanta, GA 30329 USA.;ejacobs@cancer.org
    1. Year: 2010
    2. Date: Sep
  2. Journal: International Journal of Cancer
    1. 127
    2. 6
    3. Pages: 1421-1428
  4. Type of Article: Article
  5. ISSN: 0020-7136
  1. Abstract:

    A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (Cl) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% Cl = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% Cl = 0.52-1.31), breast cancer (OR = 1.21, 95% Cl = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% Cl = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.

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  2. DOI: 10.1002/ijc.25148
  3. View record in Web of Science®
  4. WOS: 000281340100017

Library Notes

  1. Fiscal Year: FY2009-2010
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