Skip NavigationSkip to Content
Return Return to Search Results

Hundreds of variants clustered in genomic loci and biological pathways affect human height

  1. Author:
    Allen, H. L.
    Estrada, K.
    Lettre, G.
    Berndt, S. I.
    Weedon, M. N.
    Rivadeneira, F.
    Willer, C. J.
    Jackson, A. U.
    Vedantam, S.
    Raychaudhuri, S.
    Ferreira, T.
    Wood, A. R.
    Weyant, R. J.
    Segre, A. V.
    Speliotes, E. K.
    Wheeler, E.
    Soranzo, N.
    Park, J. H.
    Yang, J.
    Gudbjartsson, D.
    Heard-Costa, N. L.
    Randall, J. C.
    Qi, L.
    Smith, A. V.
    Magi, R.
    Pastinen, T.
    Liang, L.
    Heid, I. M.
    Luan, J.
    Thorleifsson, G.
    Winkler, T. W.
    Goddard, M. E.
    Lo, K. S.
    Palmer, C.
    Workalemahu, T.
    Aulchenko, Y. S.
    Johansson, A.
    Zillikens, M. C.
    Feitosa, M. F.
    Esko, T.
    Johnson, T.
    Ketkar, S.
    Kraft, P.
    Mangino, M.
    Prokopenko, I.
    Absher, D.
    Albrecht, E.
    Ernst, F.
    Glazer, N. L.
    Hayward, C.
    Hottenga, J. J.
    Jacobs, K. B.
    Knowles, J. W.
    Kutalik, Z.
    Monda, K. L.
    Polasek, O.
    Preuss, M.
    Rayner, N. W.
    Robertson, N. R.
    Steinthorsdottir, V.
    Tyrer, J. P.
    Voight, B. F.
    Wiklund, F.
    Xu, J. F.
    Zhao, J. H.
    Nyholt, D. R.
    Pellikka, N.
    Perola, M.
    Perry, J. R. B.
    Surakka, I.
    Tammesoo, M. L.
    Altmaier, E. L.
    Amin, N.
    Aspelund, T.
    Bhangale, T.
    Boucher, G.
    Chasman, D. I.
    Chen, C.
    Coin, L.
    Cooper, M. N.
    Dixon, A. L.
    Gibson, Q.
    Grundberg, E.
    Hao, K.
    Junttila, M. J.
    Kaplan, L. M.
    Kettunen, J.
    Konig, I. R.
    Kwan, T.
    Lawrence, R. W.
    Levinson, D. F.
    Lorentzon, M.
    McKnight, B.
    Morris, A. P.
    Muller, M.
    Ngwa, J. S.
    Purcell, S.
    Rafelt, S.
    Salem, R. M.
    Salvi, E.
    Sanna, S.
    Shi, J. X.
    Sovio, U.
    Thompson, J. R.
    Turchin, M. C.
    Vandenput, L.
    Verlaan, D. J.
    Vitart, V.
    White, C. C.
    Ziegler, A.
    Almgren, P.
    Balmforth, A. J.
    Campbell, H.
    Citterio, L.
    De Grandi, A.
    Dominiczak, A.
    Duan, J.
    Elliott, P.
    Elosua, R.
    Eriksson, J. G.
    Freimer, N. B.
    Geus, E. J. C.
    Glorioso, N.
    Haiqing, S.
    Hartikainen, A. L.
    Havulinna, A. S.
    Hicks, A. A.
    Hui, J. N.
    Igl, W.
    Illig, T.
    Jula, A.
    Kajantie, E.
    Kilpelaeinen, T. O.
    Koiranen, M.
    Kolcic, I.
    Koskinen, S.
    Kovacs, P.
    Laitinen, J.
    Liu, J. J.
    Lokki, M. L.
    Marusic, A.
    Maschio, A.
    Meitinger, T.
    Mulas, A.
    Pare, G.
    Parker, A. N.
    Peden, J. F.
    Petersmann, A.
    Pichler, I.
    Pietilainen, K. H.
    Pouta, A.
    Riddertrale, M.
    Rotter, J. I.
    Sambrook, J. G.
    Sanders, A. R.
    Sanders, A. R.
    Schmidt, C. O.
    Sinisalo, J.
    Smit, J. H.
    Stringham, H. M.
    Walters, G. B.
    Widen, E.
    Wild, S. H.
    Willemsen, G.
    Zagato, L.
    Zgaga, L.
    Zitting, P.
    Alavere, H.
    Farrall, M.
    McArdle, W. L.
    Nelis, M.
    Peters, M. J.
    Ripatti, S.
    Meurs, J. B. J.
    Aben, K. K.
    Ardlie, K. G.
    Beckmann, J. S.
    Beilby, J. P.
    Bergman, R. N.
    Bergmann, S.
    Collins, F. S.
    Cusi, D.
    den Heijer, M.
    Eiriksdottir, G.
    Gejman, P. V.
    Hall, A. S.
    Hamsten, A.
    Huikuri, H. V.
    Iribarren, C.
    Kahonen, M.
    Kaprio, J.
    Kathiresan, S.
    Kiemeney, L.
    Kocher, T.
    Launer, L. J.
    Lehtimaki, T.
    Melander, O.
    Mosley, T. H.
    Musk, A. W.
    Nieminen, M. S.
    O'Donnell, C. J.
    Ohlsson, C.
    Oostra, B.
    Palmer, L. J.
    Raitakari, O.
    Ridker, P. M.
    Rioux, J. D.
    Rissanen, A.
    Rivolta, C.
    Schunkert, H.
    Shuldiner, A. R.
    Siscovick, D. S.
    Stumvoll, M.
    Tonjes, A.
    Tuomilehto, J.
    van Ommen, G. J.
    Viikari, J.
    Heath, A. C.
    Martin, N. G.
    Montgomery, G. W.
    Province, M. A.
    Kayser, M.
    Arnold, A. M.
    Atwood, L. D.
    Boerwinkle, E.
    Chanock, S. J.
    Deloukas, P.
    Gieger, C.
    Gronberg, H.
    Hall, P.
    Hattersley, A. T.
    Hengstenberg, C.
    Hoffman, W.
    Lathrop, G. M.
    Salomaa, V.
    Schreiber, S.
    Uda, M.
    Waterworth, D.
    Wright, A. F.
    Assimes, T. L.
    Barroso, I.
    Hofman, A.
    Mohlke, K. L.
    Boomsma, D. I.
    Caulfield, M. J.
    Cupples, L. A.
    Erdmann, J.
    Fox, C. S.
    Gudnason, V.
    Gyllensten, U.
    Harris, T. B.
    Hayes, R. B.
    Jarvelin, M. R.
    Mooser, V.
    Munroe, P. B.
    Ouwehand, W. H.
    Penninx, B. W.
    Pramstaller, P. P.
    Quertermous, T.
    Rudan, I.
    Samani, N. J.
    Spector, T. D.
    Volzke, H.
    Watkins, H.
    Wilson, J. F.
    Groop, L. C.
    Haritunians, T.
    Hu, F. B.
    Kaplan, R. C.
    Metspalu, A.
    North, K. E.
    Schlessinger, D.
    Wareham, N. J.
    Hunter, D. J.
    O'Connell, J. R.
    Strachan, D. P.
    Schadt, H. E.
    Thorsteinsdottir, U.
    Peltonen, L.
    Uitterlinden, A. G.
    Visscher, P. M.
    Chatterjee, N.
    Loos, R. J. F.
    Boehnke, M.
    McCarthy, M. I.
    Ingelsson, E.
    Lindgren, C. M.
    Abecasis, G. R.
    Stefansson, K.
    Frayling, T. M.
    Hirschhorn, J. N.
    Procardis, C.

  2. Author Address

    [Allen, Hana Lango; Weedon, Michael N.; Wood, Andrew R.; Perry, John R. B.; Hattersley, Andrew T.; Frayling, Timothy M.] Univ Exeter, Peninsula Coll Med & Dent, Exeter EX1 2LU, Devon, England. [Estrada, Karol; Rivadeneira, Fernando; Aulchenko, Yurii S.; Amin, Najaf; vVan Meurs, Joyce B. J.; Hofman, Albert; Uitterlinden, Andre G.] Erasmus Sch Ctr, Dept Epidemiol, NL-3015 GE Rotterdam, Netherlands. [Estrada, Karol; Rivadeneira, Fernando; Zillikens, M. Carola; Peters, Marjolein J.; vVan Meurs, Joyce B. J.; Uitterlinden, Andre G.] Erasmus MC, Dept Internal Med, NL-3015 GE Rotterdam, Netherlands. [Estrada, Karol; Rivadeneira, Fernando; Aulchenko, Yurii S.; Peters, Marjolein J.; vVan Meurs, Joyce B. J.; Hofman, Albert; Uitterlinden, Andre G.] NCHA, NGI, NL-42300 RC Leiden, Netherlands. [Lettre, Guillaume; Lo, Ken Sin; Boucher, Gabrielle; Rioux, John D.] Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada. [Lettre, Guillaume; Rioux, John D.] Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada. [Berndt, Sonja I.; Park, Ju-Hyun; Shi, Jianxin; Chatterjee, Nilanjan] Natl Canc Inst, Natl Inst Hlth, Divis Canc Epidemiol & Genet, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Willer, Cristen J.; Jackson, Anne U.; Weyant, Robert J.; Stringham, Heather M.; Boehnke, Michael; Abecasis, Goncalo R.] Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA. [Vedantam, Sailaja; Palmer, Cameron; Altmaier, Elizabeth L.; Salem, Rany M.; Turchin, Michael C.] Childrens Hosp, Div Genet & Endocrinol, Boston, MA 02115 USA. [Vedantam, Sailaja; Palmer, Cameron; Altmaier, Elizabeth L.; Salem, Rany M.; Turchin, Michael C.] Childrens Hosp, Program Gen, Boston, MA 02115 USA. [Vedantam, Sailaja; Palmer, Cameron; Altmaier, Elizabeth L.; Salem, Rany M.; Turchin, Michael C.] Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA. [Raychaudhuri, Soumya; Segre, Ayellet V.; Voight, Benjamin F.; Ardlie, Kristin G.; Kathiresan, Sekar] MIT, Program Med & Populat Genet, Cambridge, MA 02142 USA. [Raychaudhuri, Soumya; Segre, Ayellet V.; Voight, Benjamin F.; Ardlie, Kristin G.; Kathiresan, Sekar] Broad Inst Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA. [Raychaudhuri, Soumya] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA. [Ferreira, Teresa; Randall, Joshua C.; Maegi, Reedik; Prokopenko, Inga; Rayner, Nigel W.; Robertson, Neil R.; Morris, Andrew P.; Peden, John F.; Farrall, Martin; Watkins, Hugh; McCarthy, Mark I.; Lindgren, Cecilia M.; Procardis Consortium] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England. [Segre, Ayellet V.; Voight, Benjamin F.; Purcell, Shaun; Kathiresan, Sekar] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA. [Segre, Ayellet V.; Voight, Benjamin F.] Massachusetts Gen Hosp, Dept Biol Mol, Boston, MA 02114 USA. [Speliotes, Elizabeth K.; Kaplan, Lee M.] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA. [Wheeler, Eleanor; Soranzo, Nicole; Grundberg, Elin; Chanock, Stephen J.; Deloukas, Panos; Barroso, Ines; Ouwehand, Willem H.; Peltonen, Leena] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England. [Soranzo, Nicole; Mangino, Massimo; Spector, Timothy D.] Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England. [Yang, Jian; Visscher, Peter M.] Queensland Inst Med Res, Queensland Stat Genet Lab, Queensland 4006, Australia. [Gudbjartsson, Daniel; Thorleifsson, Gudmar; Steinthorsdottir, Valgerdur; Walters, G. Bragi; Thorsteinsdottir, Unnur; Stefansson, Kari] deCODE Genet, IS-101 Reykjavik, Iceland. [Heard-Costa, Nancy L.; Atwood, Larry D.] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA. [Qi, Lu; Workalemahu, Tsegaselassie; Hu, Frank B.; Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Qi, Lu; Pietilainen, Kirsi H.; Kaprio, Jaakko; Hu, Frank B.; Hunter, David J.] Harvard Univ, Sch Med, Dept Nutr, Boston, MA 02115 USA. [Qi, Lu; Hu, Frank B.; Hunter, David J.] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA. [Smith, Albert Vernon; Aspelund, Thor; Eiriksdottir, Gudny; Gudnason, Vilmundur] Iceland Heart Assoc, Kopavogur, Iceland. [Smith, Albert Vernon; Aspelund, Thor; Gudnason, Vilmundur] Univ Iceland, IS-101 Reykjavik, Iceland. [Pastinen, Tomi; Grundberg, Elin; Kwan, Tony; Verlaan, Dominique J.] McGill Univ, Montreal, PQ H3A 1A4, Canada. [Pastinen, Tomi; Grundberg, Elin; Kwan, Tony; Verlaan, Dominique J.] Genome Quebec Innovat Ctr, Montreal, PQ H3A 1A4, Canada. [Pastinen, Tomi; Grundberg, Elin; Kwan, Tony; Verlaan, Dominique J.] McGill Univ, Ctr Hlth, Dept Human Genet, Montreal, PQ H3G 1A4, Canada. [Liang, Liming] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Cambridge, MA 02138 USA. [Liang, Liming] Harvard Univ, Sch Publ Hlth, Dept Biostat, Cambridge, MA 02138 USA. [Heid, Iris M.; Winkler, Thomas W.] Univ Regensburg, Med Ctr, Dept Epidemiol & Prevent Med, D-93053 Regensburg, Germany. [Heid, Iris M.; Albrecht, Eva; Mueller, Martina; Illig, Thomas; Gieger, Christian; Schadt, H. -Erich] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, D-85764 Neuherberg, Germany. [Luan, Jian'an; Zhao, Jing Hua; Kilpelaeinen, Tuomas O.; Wareham, Nicholas J.; Loos, Ruth J. F.] Addenbrookes Hosp, Inst Met Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England. [Goddard, Michael E.] Univ Melbourne, Fac Land & Environm, Parkville, Vic 3010, Australia. [Goddard, Michael E.] Dept Primary Ind, Bundoora, Vic 3086, Australia. [Johansson, Asa; Igl, Wilmar; Gyllensten, Ulf] Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, SE-75185 Uppsala, Sweden. [Johansson, Asa] Norwegian Univ Sci & Technol NTNU, Dept Canc Res & Mol Med, Fac Med, N-7489 Trondheim, Norway. [Feitosa, Mary F.; Ketkar, Shamika; Province, Michael A.] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA. [Esko, Tonu; Tammesoo, Mari-Liis; Alavere, Helene; Nelis, Mari] Univ Tartu, Estonian Genome Ctr, EE-50410 Tartu, Estonia. [Esko, Tonu; Nelis, Mari; Metspalu, Andres] Estonian Bioctr, EE-51010 Tartu, Estonia. [Esko, Tonu; Nelis, Mari; Metspalu, Andres] Univ Tartu, Inst Mol & Cell Biol, EE-51010 Tartu, Estonia. [Johnson, Toby; Kutalik, Zoltan; Beckmann, Jacques S.; Bergmann, Sven; Rivolta, Carlo] Univ Lausanne, Dept Med Genet, CH-1005 Lausanne, Switzerland. [Johnson, Toby; Kutalik, Zoltan; Bergmann, Sven] Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland. [Johnson, Toby] Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, London EC1M 6BQ, England. [Johnson, Toby; Caulfield, Mark J.; Munroe, Patricia B.] Univ London, William Harvey Res Inst, Barts & London Genome Ctr, Barts & London Sch Med & Dent, London EC1M6BQ, England. [Kraft, Peter; Hu, Frank B.; Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Prokopenko, Inga; Rayner, Nigel W.; Robertson, Neil R.; Lindgren, Cecilia M.] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England. [Absher, Devin] Hudson Alpha Inst Biotechnol, Huntsville, AL 35806 USA. [Ernst, Florian] Ernst Moritz Arndt Univ Greifswald, Interfac Inst Genet & Funct Gen, D-17487 Greifswald, Germany. [Glazer, Nicole L.; Wiklund, Fredrik] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA. [Glazer, Nicole L.; Wiklund, Fredrik] Univ Washington, Dept Med, Seattle, WA 98101 USA. [Hayward, Caroline; Xu, Jianfeng; Vitart, Veronique; Wright, Alan F.; Rudan, Igor] Western Gen Hosp, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland. [Hottenga, Jouke-Jan; Geus, Eco J. C.; Willemsen, Gonneke; Boomsma, Dorret I.] Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands. [Jacobs, Kevin B.] NCI Frederick, SAIC Frederick Inc, Frederick, MD 21702 USA. [Knowles, Joshua W.; Assimes, Themistocles L.; Quertermous, Thomas] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA. [Monda, Keri L.; North, Kari E.] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27514 USA. [Polasek, Ozren; Kolcic, Ivana; Zgaga, Lina] Univ Zagreb, Andrija Stampar Sch Publ Hlth, Sch Med, Zagreb 10000, Croatia. [Polasek, Ozren] Gen Info Ltd, Zagreb 10000, Croatia. [Preuss, Michael; Koenig, Inke R.] Univ Lubeck, Inst Med Biometrie & Stat, D-23562 Lubeck, Germany. [Tyrer, Jonathan P.] Univ Cambridge, Dept Oncol, Cambridge CB1 8RN, England. [Gronberg, Henrik; Hall, Per; Ingelsson, Erik] Karolinska Inst, Dept Med Epidemiol & Biostatist, S-17177 Stockholm, Sweden. [Shuldiner, Alan R.] Wake Forest Univ, Ctr Human Genome, Winston Salem, NC 27157 USA. [Nyholt, Dale R.] Queensland Inst Med Res, Neurogenet Lab, Queensland 4006, Australia. [Pellikka, Niina; Perola, Markus; Surakka, Ida; Kettunen, Johannes; Widen, Elisabeth; Ripatti, Samuli; Kaprio, Jaakko] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki 00014, Finland. [Pellikka, Niina; Perola, Markus; Surakka, Ida; Kettunen, Johannes; Ripatti, Samuli; Peltonen, Leena] Natl Inst Hlth & Welfare, Dept Chron Dis Prevent, Unit Publ Hlth Gen, FIN-00014 Helsinki, Finland. [Bhangale, Tushar] Univ Washington, Dept Gen Sci, Seattle, WA 98195 USA. [Chasman, Daniel I.; Ridker, Paul M.] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA. [Chasman, Daniel I.; Kaplan, Lee M.; Ridker, Paul M.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Chen, Constance] Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, Boston, MA 02115 USA. [Coin, Lachlan; Sovio, Ulla; Elliott, Paul] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Fac Med, Dept Epidemiol & Biostat, London W2 1PG, England. [Cooper, Matthew N.; Lawrence, Robert W.; Hui, Jennie; Palmer, Lyle J.] Univ Western Australia, Ctr Genet Epidemiol & Biostatist, Crawley, WA 6009, Australia. [Dixon, Anna L.] Univ Bath, Bath BA1 1RL, Avon, England. [Dixon, Anna L.] Royal Natl Hosp Rheumat Dis, Bath BA1 1RL, Avon, England. [Gibson, Quince; Haiqing, Shen; Shuldiner, Alan R.; O'Connell, Jeffrey R.] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA. [Hao, Ke] Rosetta Inpharmat Wholly Owned Subsidiary Merck&C, Dept Genet, Seattle, WA 98109 USA. [Junttila, M. Juhani; Huikuri, Heikki V.] Univ Oulu, Dept Internal Med, Oulu 90014, Finland. [Kaplan, Lee M.] Massachusetts Gen Hosp, MGH Weight Ctr, Boston, MA 02114 USA. [Levinson, Douglas F.] Stanford Univ, Sch ofMedicine, Stanford, CA 93405 USA. [Lorentzon, Mattias; Vandenput, Liesbeth; Ohlsson, Claes] Univ Gothenburg, Inst Med, Dept Internal Med, Sahlgrenska Acad, S-41345 Gothenburg, Sweden. [McKnight, Barbara; Arnold, Alice M.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Mueller, Martina] Univ Munich, Dept Med 1, Univ Hosp Grosshadern, D-81377 Munich, Germany. [Mueller, Martina; Schadt, H. -Erich] Univ Munich, Inst Med Informat Biometry & Epidemiol, Chair Epidemiol, D-81377 Munich, Germany. [Ngwa, Julius Suh; White, Charles C.; Cupples, L. Adrienne] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA. [Purcell, Shaun; Schreiber, Stefan; Peltonen, Leena] Broad Inst Harvard, Cambridge, MA 02142 USA. [Purcell, Shaun; Peltonen, Leena] MIT, Cambridge, MA 02142 USA. [Purcell, Shaun] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Rafelt, Suzanne; Samani, Nilesh J.] Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, Leicester LE3 9QP, Leics, England. [Salvi, Erika; Cusi, Daniele] Univ Milan, Dept Med Surg & Dent, I-20139 Milan, Italy. [Salvi, Erika] KOS Genet Srl, I-20123 Milan, Italy. [Sanna, Serena; Maschio, Andrea; Mulas, Antonella; Uda, Manuela] Ist Neurogenet & Neurofarmacol CNR, I-09042 Cagliari, Italy. [Thompson, John R.; Samani, Nilesh J.] Glenfield Hosp, Leicester NIHR Biomed Res Unit Cardiovasc Dis, Leicester LE3 9QP, Leics, England. [Thompson, John R.] Univ Leicester, Dept Hlth Sci, Leicester LE1 7RH, Leics, England. [Ziegler, Andreas] Univ Lubeck, Inst Med Biometrie & Stat, D-23562 Lubeck, Germany. [Almgren, Peter; Groop, Leif C.] Lund Univ, Ctr Diabet, Dept Clin Sci, S-20502 Malmo, Sweden. [Balmforth, Anthony J.; Hall, Alistair S.] Univ Leeds, Multidisciplinary Cardiovasc Res Ctr, Leeds Inst Genet Hlth & Therapeut, Leeds LS2 9JT, W Yorkshire, England. [Campbell, Harry; Wild, Sarah H.; Wilson, James F.] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9AG, Midlothian, Scotland. [Citterio, Lorena; Zagato, Laura] Univ Vita Salute San Raffaele, Div Nephrol & Dialysis, I-20132 Milan, Italy. [De Grandi, Alessandro; Dominiczak, Anna; Hicks, Andrew A.; Pichler, Irene; Pramstaller, Peter P.] European Acad Bozen Bolzano EURAC, Inst Med Genet, I-39100 Bolzano, Italy. [De Grandi, Alessandro; Dominiczak, Anna; Hicks, Andrew A.; Pichler, Irene; Pramstaller, Peter P.] Univ Lubeck, Affiliated Inst, Lubeck, Germany. [Strachan, David P.] Univ Glasgow, British Heart Fdn Glasgow Cardiovascular Res Ct, Glasgow G12 8TA, Lanark, Scotland. [Duan, Jubao; Sanders, Alan R.; Gejman, Pablo V.] Northshore Univ Healthsyst, Evanston, IL 60201 USA. [Elosua, Roberto; Eriksson, Johan G.] Inst Municipal Invest Medica & CIBER Epidemiol &, Barcelona, Spain. Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki 00014, Finland. [Eriksson, Johan G.; Kajantie, Eero] Natl Inst Hlth & Welf, Helsinki 00271, Finland. [Eriksson, Johan G.] Univ Helsinki, Cent Hosp, Unit Gen Practice, Helsinki 00280, Finland. [Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki 00250, Finland. [Eriksson, Johan G.] Vasa Cent Hosp, Vaasa 65130, Finland. [Freimer, Nelson B.] Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA 90095 USA. [Glorioso, Nicola] Univ Sassari, Hypertens & Cardiovasc Prevent Ctr, I-07100 Sassari, Italy. [Hartikainen, Anna-Liisa; Pouta, Anneli] Univ Oulu, Dept Clin Sci Obstet & Gynecol, Oulu 90014, Finland. [Havulinna, Aki S.; Koskinen, Seppo; Salomaa, Veikko] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Chron Dis Epidemiol & Prevent Unit, Helsinki 00014, Finland. [Hui, Jennie; Beilby, John P.] QEII Med Ctr, PathW Lab Western Australia, Dept Mol Genet, Nedlands, WA 6009, Australia. [Hui, Jennie; Beilby, John P.; Musk, Arthur W.; Palmer, Lyle J.] Sir Charles Gairdner Hosp, Busselton Populat Med Res Fdn Inc, Nedlands, WA, Australia. [Jula, Antti] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Populat Studies Unit, Turku 20720, Finland. [Koiranen, Markku; Jarvelin, Marjo-Ritta] Univ Oulu, Inst Hlth Sci, Oulu 90014, Finland. [Kovacs, Peter] Univ Leipzig, Interdisciplinary Ctr Clin Res, D-04103 Leipzig, Germany. [Laitinen, Jaana] Finnish Inst Occupat Hlth, Oulu 90220, Finland. [Liu, Jianjun] Genome Inst Singapore, Singapore 138672, Singapore. [Lokki, Marja-Liisa] Univ Helsinki, Haartman Inst, Transplantat Lab, Helsinki 00014, Finland. [Marusic, Ana; Rudan, Igor] Univ Split, Sch Med, Croatian Ctr Global Hlth, Split 21000, Croatia. [Meitinger, Thomas] Klinikum Rechts Isar Techn Univ Mu nchen, Inst Human Genet, D-81675 Munich, Germany. [Meitinger, Thomas] Helmholtz Zentrum Munchen German Res Ctr Environm, Inst Human Genet, D-85764 Neuherberg, Germany. [Pare, Guillaume] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8N 3Z5, Canada. [Parker, Alex N.] Amgen Inc, Cambridge, MA 02139 USA. [Peden, John F.; Farrall, Martin; Watkins, Hugh; Procardis Consortium] Univ Oxford, John Radcliffe Hosp, Dept Cardiovasc Med, Oxford OX3 9DU, England. [Petersmann, Astrid] Ernst Moritz Arndt Univ Greifswald, Inst Klin Chem, D-17475 Greifswald, Germany. [Petersmann, Astrid] Ernst Moritz Arndt Univ Greifswald, Lab Med, D-17475 Greifswald, Germany. [Pietilainen, Kirsi H.; Kaprio, Jaakko] Univ Helsinki, Dept Publ Hlth, Helsinki 00014, Finland. [Pietilainen, Kirsi H.; Rissanen, Aila] Univ Helsinki, Cent Hosp, Dept Psychiat, Obes Res unit, Helsinki, Finland. [Pouta, Anneli; Jarvelin, Marjo-Ritta] Natl Inst Hlth & Welf, Oulu 90101, Finland. [Riddertrale, Martin; Melander, Olle] Lund Univ, Dept Clin Sci, S-20502 Maimo, Sweden. [Sambrook, Jennifer G.; Ouwehand, Willem H.] Univ Cambridge, Dept Haematol, Cambridge CB2 OPT, England. [Sambrook, Jennifer G.; Ouwehand, Willem H.] Cambridge Ctr, Cambridge CB2 0PT, England. [Schmidt, Carsten Oliver; Hoffman, Wolfgang; Voelzke, Henry] Inst Community Med, D-17489 Greifswald, Germany. [Sinisalo, Juha; Nieminen, Markku S.] Univ Helsinki, Cent Hosp, Cardiovasc Lab, Div Cardiol, Helsinki 00029, Finland. [Smit, Jan H.; Penninx, Brenda W.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiatry EMGO Inst, NL-1081 BT Amsterdam, Netherlands. [Zitting, Paavo] Lapland Cent Hosp, Dept Physiat, Rovaniemi 96101, Finland. [Farrall, Martin] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England. [McArdle, Wendy L.] Univ Bristol, Dept Social Med, ALSPAC, Bristol BS8 2BN, Avon, England. [Aben, Katja K.; Kiemeney, Lambertus] Comprehens Canc Ctr E, NL-6501 BG Nijmegen, Netherlands. [Beckmann, Jacques S.] CHUV, Univ Hosp, Serv Med Genet, CH-1011 Lausanne, Switzerland. [Beilby, John P.] Univ Western Australia, Sch Pathol & Lab Med, Nedlands, WA 6009, Australia. [Bergman, Richard N.] Univ So Calif, Keck Sch Med, Dept Phys & Biophys, Los Angeles, CA 90033 USA. [Collins, Francis S.] Natl Human Genome Res Inst, Natl Inst Hlth, Bethesda, MD 20892 USA. [den Heijer, Martin] Radboud Univ Nijmegen, Med Ctr, Dept Endocrinol, NL-6500 HB Nijmegen, Netherlands. [Hamsten, Anders] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Atherosclerosis Res Unit, S-17176 Solna, Sweden. [Iribarren, Carlos] Kaiser Permanente No Calif, Div Res, Oakland, CA 94612 USA. [Iribarren, Carlos] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94107 USA. [Kahonen, Mika] Univ Tampere, Dept Clin Physiol, Tampere 33520, Finland. [Kahonen, Mika] Tampere Univ Hosp, Tampere 33520, Finland. [Kaprio, Jaakko] Natl Inst Hlth & Welf, Dept Mental Hlth & Substance Abuse Serv, Unit Child & Adolescent Mental Hlth, Helsinki 00271, Finland. [Kathiresan, Sekar; McCarthy, Mark I.] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA. [Kathiresan, Sekar; McCarthy, Mark I.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Kathiresan, Sekar; O'Donnell, Christopher J.] Boston Univ, Framingham, MA 01702 USA. [Kathiresan, Sekar; O'Donnell, Christopher J.] NHLBI, Framingham Heart Study, Framingham, MA 01702 USA. [Kathiresan, Sekar] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA. [Kiemeney, Lambertus] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostatist & HTA, NL-6500 HB Nijmegen, Netherlands. [Kiemeney, Lambertus] Radboud Univ Nijmegen, Med Ctr, Dept Urol, NL-6500 HB Nijmegen, Netherlands. [Kocher, Thomas] Zentrum Zahn Mund & Kieferheilkunde, D-17489 Greifswald, Germany. [Launer, Lenore J.; Harris, Tamara B.] Natl Inst Hlth, NIA, Lab Epidemiol Demog, Bethesda, MD 20892 USA. [Lehtimaki, Terho] Univ Tampere, Dept Clin Chem, Tampere 33520, Finland. [Lehtimaki, Terho] Tampere Univ Hosp, Dept Clin Chem, Tampere 33520, Finland. [Mosley, Tom H., Jr.] Univ Mississippi, Div Geriatr, Med Ctr, Dept Med, Jackson, MS 39216 USA. [Musk, Arthur W.] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia. [O'Donnell, Christopher J.] Natl Inst Hlth, Nat Lung & Blood Inst, Framingham, MA 01702 USA. [Oostra, Ben] Erasmus MC, Dept Clin Genet, NL-3015 GE Rotterdam, Netherlands. [Raitakari, Olli] Turku Univ, Res Ctr Appl & Prevent Cardiovasc Med, Turku 20520, Finland. [Raitakari, Olli] Turku Univ Hosp, Dept Clin Physiol, Turku 20520, Finland. [Schunkert, Heribert; Erdmann, Jeanette] Univ Lubeck, Med Klin 2, D-23562 Lubeck, Germany. [Shuldiner, Alan R.] Baltimore Vet Adm Med Ctr, Geriatr Res & Educ Clin Ctr, Baltimore, MD 21201 USA. [Siscovick, David S.] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA. [Siscovick, David S.] Univ Washington, Dept Med, Seattle, WA 98195 USA. [Siscovick, David S.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA. [Stumvoll, Michael; Toenjes, Anke] Univ Leipzig, Dept Med, D-04103 Leipzig, Germany. [Stumvoll, Michael] Univ Leipzig, LIFE Study Ctr, Leipzig, Germany. [Toenjes, Anke] Univ Leipzig, Coordinat Ctr Clin Trials, D-04103 Leipzig, Germany. [Tuomilehto, Jaakko] Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki 00271, Finland. [Tuomilehto, Jaakko] Univ Helsinki, Dept Publ Hlth, Hjelt Inst, Helsinki 00014, Finland. [Tuomilehto, Jaakko] S Ostrobothnia Cent Hosp, Seinajoki 60220, Finland. [van Ommen, Gert-Jan] Leiden Univ, Med Ctr, Dept Human Genet, NL-2333 ZC Leiden, Netherlands. [van Ommen, Gert-Jan] Leiden Univ, Med Ctr, Ctr Med Syst Biol, NL-2333 ZC Leiden, Netherlands. [Viikari, Jorma] Univ Turku, Dept Med, Turku 20520, Finland. [Viikari, Jorma] Turku Univ Hosp, Turku 20520, Finland. [Heath, Andrew C.] Washington Univ, Sch Med, Dept Psychiat & Midwest, Res Inst Alcoholism, St Louis, MO 63108 USA. [Martin, Nicholas G.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. [Montgomery, Grant W.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. [Province, Michael A.] Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA. [Kayser, Manfred] Erasmus MC, Dept Forens Mol Biol, NL-3015 GE Rotterdam, Netherlands. [Arnold, Alice M.] Collaborat Hlth Studies Coordinating Ctr, Seattle, WA 98115 USA. [Boerwinkle, Eric] Univ Texas Houston, Hlth Sci Ctr, Ctr Human Genet, Houston, TX 77030 USA. [Boerwinkle, Eric] Univ Texas Houston, Hlth Sci Ctr, Inst Mol Med, Houston, TX 77030 USA. [Boerwinkle, Eric] Univ Texas Houston, Hlth Sci Ctr, Div Epidemiol, Houston, TX 77030 USA. [Hengstenberg, Christian] Univ Regensburg, Klin & Poliklin Innere Med 2, D-93053 Regensburg, Germany. [Hengstenberg, Christian] Univ Regensburg, Med Ctr, Innere Med 2, D-93053 Regensburg, Germany. [Lathrop, G. Mark] Ctr Natl Genotypage, F-91057 Paris, France. [Schreiber, Stefan] Univ Kiel, Univ Hosp Schleswig Holstein, Clin Mol Biol, D-24105 Kiel, Germany. [Schreiber, Stefan] Dept Internal Med 1, D-24105 Kiel, Germany. [Waterworth, Dawn; Mooser, Vincent] GlaxoSmithKline Inc, Div Genet, King Of Prussia, PA 19406 USA. [Barroso, Ines] Addenbrookes Hosp, Metab Res Labs, Inst Metab Sci, Cambridge CB2 OQQ, England. [Fox, Caroline S.] NHLBI, Div Intramural Res, Framingham, MA 01702 USA. [Hayes, Richard B.] NYU, Med Ctr, New York, NY 10016 USA. [Jarvelin, Marjo-Ritta] Univ Oulu, Bioctr Oulu, Oulu 90014, Finland. [Penninx, Brenda W.] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RC Leiden, Netherlands. [Penninx, Brenda W.] Univ Med Ctr Groningen, Dept Psychiat, NL-9713 GZ Groningen, Netherlands. [Pramstaller, Peter P.] Gen Cent Hosp, Dept Neurol, Bolzano, Italy. [Kaplan, Robert C.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA. [North, Kari E.] Univ N Carolina, Sch Publ Hlth, Carolina Ctr Genome Sci, Chapel Hill, NC 27514 USA. [Schlessinger, David] NIA, Genet Lab, Baltimore, MD 21224 USA. [Strachan, David P.] St Georges Univ London, Div Community Hlth Sci, London SW17 0RE, England. [Schadt, H. -Erich] Klinikum Grosshadern, D-81377 Munich, Germany. [Eriksson, Johan G.] Pacif Biosci, Menlo Pk, CA 94025 USA. Sage Bionetworks, Seattle, WA 98109 USA. [Thorsteinsdottir, Unnur] Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland. [Peltonen, Leena] Univ Helsinki, Dept Med Genet, Helsinki 00014, Finland. [McCarthy, Mark I.] Churchill Hosp, NIHR Oxford Biomed Res Ctr, Oxford OX3 7LJ, England. [Hirschhorn, Joel N.] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.\\Allen, HL, Univ Exeter, Peninsula Coll Med & Dent, Exeter EX1 2LU, Devon, England.
    1. Year: 2010
    2. Date: Oct
  2. Journal: Nature
    1. 467
    2. 7317
    3. Pages: 832-838
  4. Type of Article: Article
  5. ISSN: 0028-0836
  1. Abstract:

    Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1038/nature09410
  3. PMID: 20881960
  4. View record in Web of Science®
  5. WOS: 000282898700065

Library Notes

  1. Fiscal Year: FY2010-2011
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel