Skip NavigationSkip to Content
Return Return to Search Results

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

  1. Author:
    Rothman, N.
    Garcia-Closas, M.
    Chatterjee, N.
    Malats, N.
    Wu, X. F.
    Figueroa, J. D.
    Real, F. X.
    Van den Berg, D.
    Matullo, G.
    Baris, D.
    Thun, M.
    Kiemeney, L. A.
    Vineis, P.
    De Vivo, I.
    Albanes, D.
    Purdue, M. P.
    Rafnar, T.
    Hildebrandt, M. A. T.
    Kiltie, A. E.
    Cussenot, O.
    Golka, K.
    Kumar, R.
    Taylor, J. A.
    Mayordomo, J. I.
    Jacobs, K. B.
    Kogevinas, M.
    Hutchinson, A.
    Wang, Z. W.
    Fu, Y. P.
    Prokunina-Olsson, L.
    Burdett, L.
    Yeager, M.
    Wheeler, W.
    Tardon, A.
    Serra, C.
    Carrato, A.
    Garcia-Closas, R.
    Lloreta, J.
    Johnson, A.
    Schwenn, M.
    Karagas, M. R.
    Schned, A.
    Andriole, G.
    Grubb, R.
    Black, A.
    Jacobs, E. J.
    Diver, W. R.
    Gapstur, S. M.
    Weinstein, S. J.
    Virtamo, J.
    Cortessis, V. K.
    Gago-Dominguez, M.
    Pike, M. C.
    Stern, M. C.
    Yuan, J. M.
    Hunter, D. J.
    McGrath, M.
    Dinney, C. P.
    Czerniak, B.
    Chen, M.
    Yang, H. S.
    Vermeulen, S. H.
    Aben, K. K.
    Witjes, J. A.
    Makkinje, R. R.
    Sulem, P.
    Besenbacher, S.
    Stefansson, K.
    Riboli, E.
    Brennan, P.
    Panico, S.
    Navarro, C.
    Allen, N. E.
    Bueno-De-Mesquita, H. B.
    Trichopoulos, D.
    Caporaso, N.
    Landi, M. T.
    Canzian, F.
    Ljungberg, B.
    Tjonnel, A.
    Clavel-Chapelon, F.
    Bishop, D. T.
    Teo, M. T. W.
    Knowles, M. A.
    Guarrera, S.
    Polidoro, S.
    Ricceri, F.
    Sacerdote, C.
    Allione, A.
    Cancel-Tassin, G.
    Selinski, S.
    Hengstler, J. G.
    Dietrich, H.
    Fletcher, T.
    Rudnai, P.
    Gurzau, E.
    Koppova, K.
    Bolick, S. C. E.
    Godfrey, A.
    Xu, Z. L.
    Sanz-Velez, J. I.
    Garcia-Prats, M. D.
    Sanchez, M.
    Valdivia, G.
    Porru, S.
    Benhamou, S.
    Hoover, R. N.
    Fraumeni, J. F.
    Silverman, D. T.
    Chanock, S. J.

  2. Author Address

    [Rothman, Nathaniel; Garcia-Closas, Montserrat; Chatterjee, Nilanjan; Figueroa, Jonine D.; Baris, Dalsu; Albanes, Demetrius; Purdue, Mark P.; Fu, Yi-Ping; Prokunina-Olsson, Ludmila; Black, Amanda; Weinstein, Stephanie J.; Caporaso, Neil; Landi, Maria Teresa; Hoover, Robert N.; Fraumeni, Joseph F., Jr.; Silverman, Debra T.; Chanock, Stephen J.] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Malats, Nuria; Real, Francisco X.] Spanish Natl Canc Res Ctr, Madrid, Spain. [Wu, Xifeng; Hildebrandt, Michelle A. T.; Chen, Meng; Yang, Hushan] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA. [Real, Francisco X.] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain. [Van den Berg, David; Cortessis, Victoria K.; Gago-Dominguez, Manuela; Pike, Malcolm C.; Stern, Mariana C.] Univ So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90089 USA. [Matullo, Giuseppe] Univ Turin, Dept Genet Biol & Biochem, Turin, Italy. [Matullo, Giuseppe; Vineis, Paolo; Guarrera, Simonetta; Polidoro, Silvia; Ricceri, Fulvio; Sacerdote, Carlotta; Allione, Alessandra] Human Genet Fdn HuGeF, Turin, Italy. [Thun, Michael; Jacobs, Eric J.; Diver, W. Ryan; Gapstur, Susan M.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA. [Kiemeney, Lambertus A.; Vermeulen, Sita H.; Aben, Katja K.] Radboud Univ Nijmegen Med Ctr, Dept Epidemiol Biostat & Hlth Technol Assessment, Nijmegen, Netherlands. [Kiemeney, Lambertus A.] Comprehens Canc Ctr E, Nijmegen, Netherlands. [Kiemeney, Lambertus A.; Witjes, J. Alfred] Radboud Univ Nijmegen Med Ctr, Dept Urol, Nijmegen, Netherlands. [Vineis, Paolo; Riboli, Elio] Univ London Imperial Coll Sci Technol & Med, London, England. [De Vivo, Immaculata] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA. [Rafnar, Thorunn; Sulem, Patrick; Besenbacher, Soren; Stefansson, Kari] DeCODE Genet, Reykjavik, Iceland. [Kiltie, Anne E.] Univ Oxford, Gray Inst Radiat Oncol & Biol, Oxford, England. [Cussenot, Olivier] Tenon Hosp, AP HP, Dept Urol, Paris, France. [Cussenot, Olivier; Cancel-Tassin, Geraldine] Ctr Rech Pathol Prostat, Paris, France. [Golka, Klaus; Selinski, Silvia; Hengstler, Jan G.] Leibniz Res Ctr Working Environm & Human Factor, Dortmund, Germany. [Kumar, Rajiv] German Canc Res Ctr, Div Mol Genet Epidemiol, D-6900 Heidelberg, Germany. [Taylor, Jack A.; Bolick, Sophia C. E.; Godfrey, Ashley; Xu, Zongli] Natl Inst Environm Hlth Sci, Res Triangle Pk, NC USA. [Mayordomo, Jose I.; Sanchez, Manuel; Valdivia, Gabriel] Univ Zaragoza, Zaragoza, Spain. [Jacobs, Kevin B.; Hutchinson, Amy; Wang, Zhaoming; Burdett, Laurie; Yeager, Meredith] SAIC Frederick Inc, Natl Canc Inst Frederick, Core Genotype Facil, Frederick, MD USA. [Kogevinas, Manolis] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain. [Kogevinas, Manolis] Municipal Inst Med Res, Barcelona, Spain. [Kogevinas, Manolis; Tardon, Adonina; Navarro, Carmen] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain. [Kogevinas, Manolis] Natl Sch Publ Hlth, Athens, Greece. [Wheeler, William] Informat Management Serv Inc, Rockville, MD USA. [Tardon, Adonina] Univ Oviedo, Inst Univ Oncol, Oviedo, Spain. [Carrato, Alfredo] Ramon & Cajal Univ Hosp, Madrid, Spain. [Garcia-Closas, Reina] Hosp Univ Canarias, Unidad Invest, San Cristobal la Laguna, Spain. [Lloreta, Josep] Univ Pompeu Fabra, Hosp Mar Inst Municipal Invest Med IMIM, Barcelona, Spain. [Johnson, Alison] Vermont Canc Registry, Burlington, VT USA. [Schwenn, Molly] Maine Canc Registry, Augusta, ME USA. [Karagas, Margaret R.; Schned, Alan] Dartmouth Med Sch, Hanover, NH USA. [Andriole, Gerald, Jr.; Grubb, Robert, III] Washington Univ, Sch Med, Dept Urol, St Louis, MO USA. [Virtamo, Jarmo] Natl Inst Hlth & Welf, Helsinki, Finland. [Pike, Malcolm C.] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA. [Yuan, Jian-Min] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA. [Hunter, David J.; McGrath, Monica] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA. [Dinney, Colin P.] Univ Texas MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA. [Czerniak, Bogdan] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA. [Vermeulen, Sita H.; Makkinje, Remco R.] Radboud Univ Nijmegen Med Ctr, Dept Human Genet, Nijmegen, Netherlands. [Stefansson, Kari] Univ Iceland, Fac Med, Reykjavik, Iceland. [Brennan, Paul] Int Agcy Res Canc, Lyon, France. [Panico, Salvatore] Univ Naples Federico 2, Dept Clin & Expt Med, Naples, Italy. [Navarro, Carmen] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain. [Allen, Naomi E.] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England. [Bueno-de-Mesquita, H. Bas] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Trichopoulos, Dimitrios] Acad Athens, Bur Epidemiol Res, Athens, Greece. [Canzian, Federico] German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany. [Ljungberg, Borje] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden. [Tjonneland, Anne] Inst Canc Epidemiol, Danish Canc Soc, Copenhagen, Denmark. [Clavel-Chapelon, Francoise] Paris S Univ, Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, Villejuif, France. [Bishop, David T.; Teo, Mark T. W.; Knowles, Margaret A.] Univ Leeds, St Jamess Univ Hosp, Leeds Inst Mol Med, Leeds, W Yorkshire, England. [Sacerdote, Carlotta] Univ Turin, Canc Epidemiol Unit, Turin, Italy. [Dietrich, Holger] Paul Gerhardt Fdn, Dept Urol, Wittenberg, Germany. [Fletcher, Tony] Inst Hyg & Trop Med, London, England. [Rudnai, Peter] Natl Inst Environm Hlth, Budapest, Hungary. [Gurzau, Eugen] Univ Babes Bolyai, Ctr Environm Hlth, R-3400 Cluj Napoca, Romania. [Koppova, Kvetoslava] State Hlth Inst, Banska Bystrica, Slovakia. [Sanz-Velez, Jose I.; Garcia-Prats, Maria D.] San Jorge Univ Hosp, Huesca, Spain. [Porru, Stefano] Univ Brescia, Sect Occupat Med & Ind Hyg, Dept Expt & Appl Med, Brescia, Italy. [Benhamou, Simone] CEPH, Fdn Jean Dausset, U946, INSERM, Paris, France. [Benhamou, Simone] Inst Gustave Roussy, UMR8200, CNRS, Villejuif, France.;Garcia-Closas, M, NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.;montse.garciaclosas@icr.ac.uk
    1. Year: 2010
    2. Date: Nov
  2. Journal: Nature Genetics
    1. 42
    2. 11
    3. Pages: 978-U98
  4. Type of Article: Article
  5. ISSN: 1061-4036
  1. Abstract:

    We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 x 10(-12)) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 x 10(-11)) on 19q12 maps to CCNE1 and rs11892031 (P = 1 x 10(-7)) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 x 10(-11)) and a tag SNP for NAT2 acetylation status (P = 4 x 10(-11)), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1038/ng.687
  3. View record in Web of Science®
  4. WOS: 000283540500015

Library Notes

  1. Fiscal Year: FY2010-2011
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel