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Interleukin-26: An IL-10-related cytokine produced by Th17 cells

  1. Author:
    Donnelly, R. P.
    Sheikh, F.
    Dickensheets, H.
    Savan, R.
    Young, H. A.
    Walter, M. R.

  2. Author Address

    [Donnelly, Raymond P.; Sheikh, Faruk; Dickensheets, Harold] US FDA, Div Therapeut Prot, Ctr Drug Evaluat & Res, Bethesda, MD 20892 USA. [Savan, Ram; Young, Howard A.] NCI, Expt Immunol Lab, Canc & Inflammat Program, NIH, Frederick, MD 21702 USA. [Walter, Mark R.] Univ Alabama, Dept Microbiol, Birmingham, AL 35294 USA.;Donnelly, RP, US FDA, Div Therapeut Prot, Ctr Drug Evaluat & Res, Bldg 29A,Room 3B15,29 Lincoln Dr, Bethesda, MD 20892 USA.;Raymond.Donnelly@fda.hhs.gov
    1. Year: 2010
    2. Date: Oct
  2. Journal: Cytokine & Growth Factor Reviews
    1. 21
    2. 5
    3. Pages: 393-401
  4. Type of Article: Review
  5. ISSN: 1359-6101
  1. Abstract:

    IL-26 is classified as a member of the IL-10 cytokine family because it has limited sequence homology to IL-10 and the IL-10-related cytokines. The human IL-26 gene, IL26, is located on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG (IFN-gamma) and IL22 (IL-22). IL-26 is often co-expressed with IL-22 by activated T cells, especially Th17 cells. It signals through a heterodimeric receptor complex composed of the IL-20R1 and IL-10R2 chains. I1-26 receptors are primarily expressed on non-hematopoietic cell types, particularly epithelial cells. Signaling through IL-26 receptor complexes results in the activation of STAT1 and STAT3 with subsequent induction of IL-26-responsive genes. The biological functions of IL-26 have only begun to be defined. Published by Elsevier Ltd.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.cytogfr.2010.09.001
  3. View record in Web of Science®
  4. WOS: 000286122900008

Library Notes

  1. Fiscal Year: FY2010-2011
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