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Small Molecule Inhibitors as Countermeasures for Botulinum Neurotoxin Intoxication

  1. Author:
    Li, B.
    Peet, N. P.
    Butler, M. M.
    Burnett, J. C.
    Moir, D. T.
    Bowlin, T. L.

  2. Author Address

    [Li, Bing; Peet, Norton P.; Butler, Michelle M.; Moir, Donald T.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01605 USA. [Burnett, James C.] NCI, SAIC Frederick Inc, Structure Based Drug Discovery Grp, Frederick, MD 21702 USA.;Li, B, Microbiotix Inc, 1Innovat Dr, Worcester, MA 01605 USA.;bli@microbiotix.com burnettjames@mail.nih.gov
    1. Year: 2011
    2. Date: Jan
  2. Journal: Molecules
    1. 16
    2. 1
    3. Pages: 202-220
  4. Type of Article: Review
  5. ISSN: 1420-3049
  1. Abstract:

    Botulinum neurotoxins (BoNTs) are the most potent of known toxins and are listed as category A biothreat agents by the U. S. CDC. The BoNT-mediated proteolysis of SNARE proteins inhibits the exocytosis of acetylcholine into neuromuscular junctions, leading to life-threatening flaccid paralysis. Currently, the only therapy for BoNT intoxication (which results in the disease state botulism) includes experimental preventative antibodies and long-term supportive care. Therefore, there is an urgent need to identify and develop inhibitors that will serve as both prophylactic agents and post-exposure 'rescue' therapeutics. This review focuses on recent progress to discover and develop small molecule inhibitors as therapeutic countermeasures for BoNT intoxication.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/molecules16010202
  3. View record in Web of Science®
  4. WOS: 000286596400015

Library Notes

  1. Fiscal Year: FY2010-2011
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