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Polymorphisms in interferon regulatory factor 7 reduce interferon-alpha responses of plasmacytoid dendritic cells to HIV-1

  1. Author:
    Chang, J.
    Lindsay, R. J.
    Kulkarni, S.
    Lifson, J. D.
    Carrington, M.
    Altfeld, M.

  2. Author Address

    [Chang, Judy; Lindsay, Robert J.; Carrington, Mary; Altfeld, Marcus] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ragon Inst MGH MIT & Harvard, Boston, MA USA. [Kulkarni, Smita; Carrington, Mary] NCI, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD 21701 USA. [Lifson, Jeffrey D.] NCI, AIDS & Canc Virus Program, SAIC Frederick Inc, Frederick, MD 21701 USA.;Altfeld, M, Massachusetts Gen Hosp, Ragon Inst MGH MIT & Harvard, Bldg 149,13th St,6th Floor, Navy Yard, MA 02129 USA.;maltfeld@partners.org
    1. Year: 2011
    2. Date: Mar
  2. Journal: Aids
    1. 25
    2. 5
    3. Pages: 715-717
  4. Type of Article: Article
  5. ISSN: 0269-9370
  1. Abstract:

    Recognition of HIV-1 ssRNA by Toll-like receptor 7 induces the production of the pro-inflammatory cytokines that may contribute to the systemic immune activation associated with HIV-1 disease progression. Here, we describe a novel association between polymorphisms in interferon regulatory factor 7 (IRF7), a master regulator of interferon-alpha (IFN-alpha), and the ability of plasmacytoid dendritic cells to produce IFN-alpha in response to HIV-1. IRF7 polymorphisms may, therefore, affect the ability of individuals to respond to HIV-1 and modulate HIV-1 disease progression.

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External Sources

  1. View Full Text
  2. DOI: 10.1097/QAD.0b013e328343c186
  3. View record in Web of Science®
  4. WOS: 000287963600023

Library Notes

  1. Fiscal Year: FY2010-2011
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