Skip NavigationSkip to Content
Return Return to Search Results

A Common HLA-DPA1 Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese

  1. Author:
    An, P.
    Winkler, C.
    Guan, L.
    O'Brien, S. J.
    Zeng, Z.
    Consortium, H. B. V. S.

  2. Author Address

    [An, Ping; Winkler, Cheryl] NCI, Basic Res Lab, Frederick, MD 21702 USA. [Guan, Li] NCI, Lab Genom Divers, SAIC Frederick, Frederick, MD 21702 USA. [Zeng, Zheng] Peking Univ, Dept Infect Dis, Hosp 1, Beijing 100871, Peoples R China.;An, P, NCI, Basic Res Lab, Bldg 560,Rm 21-19, Frederick, MD 21702 USA.;Ping.An@nih.gov zeng@bjmu.edu.cn
    1. Year: 2011
    2. Date: Apr
  2. Journal: Journal of Infectious Diseases
    1. 203
    2. 7
    3. Pages: 943-947
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis B virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA - DPA1 rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P < .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1093/infdis/jiq154
  3. View record in Web of Science®
  4. WOS: 000288553800009

Library Notes

  1. Fiscal Year: FY2010-2011
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel