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HPV16/18 L1 VLP vaccine induces cross-neutralizing antibodies that may mediate cross-protection

  1. Author:
    Kemp, T. J.
    Hildesheim, A.
    Safaeian, M.
    Dauner, J. G.
    Pan, Y. J.
    Porras, C.
    Schiller, J. T.
    Lowy, D. R.
    Herrero, R.
    Pinto, L. A.

  2. Author Address

    [Kemp, Troy J.; Dauner, Joseph G.; Pan, Yuanji; Pinto, Ligia A.] NCI Frederick, HPV Immunol Lab, SAIC Frederick Inc, Frederick, MD 21702 USA. [Hildesheim, Allan; Safaeian, Mahboobeh] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. [Porras, Carolina; Herrero, Rolando] Fdn INCIENSA, Proyecto Epidemiol Guanacaste, San Jose, Costa Rica. [Schiller, John T.; Lowy, Douglas R.] NCI, Cellular Oncol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.;Pinto, LA, NCI Frederick, HPV Immunol Lab, SAIC Frederick Inc, Bldg 469,Room 205, Frederick, MD 21702 USA.;pintol@mail.nih.gov
    1. Year: 2011
    2. Date: Mar
  2. Journal: Vaccine
    1. 29
    2. 11
    3. Pages: 2011-2014
  4. Type of Article: Article
  5. ISSN: 0264-410X
  1. Abstract:

    Human papillomavirus (HPV) L1 VLP-based vaccines are protective against HPV vaccine-related types; however, the correlates of protection have not been defined. We observed that vaccination with Cervarix (TM) induced cross-neutralizing antibodies for HPV types for which evidence of vaccine efficacy has been demonstrated (HPV31/45) but not for other types (HPV52/58). In addition, HPV31/45 cross-neutralizing titers showed a significant increase with number of doses (HPV31, p < 0.001; HPV45, p < 0.001) and correlated with HPV16/18 neutralizing titers, respectively. These findings raise the possibility that cross-neutralizing antibodies are effectors of cross-protection observed for the HPV16/18 vaccine.(C) 2011 Elsevier Ltd. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.vaccine.2011.01.001
  3. View record in Web of Science®
  4. WOS: 000288731000004

Library Notes

  1. Fiscal Year: FY2010-2011
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