Skip NavigationSkip to Content
Return Return to Search Results

Deletion of SNAP-23 Results in Pre-Implantation Embryonic Lethality in Mice

  1. Author:
    Suh, Y. H. S. Y. H.
    Yoshimoto-Furusawa, A.
    Weih, K. A.
    Tessarollo, L.
    Roche, K. W.
    Mackem, S.
    Roche, P. A.

  2. Author Address

    [Suh, YH Suh, YH; Weih, KA; Roche, PA] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA [Suh, YH Suh, YH; Roche, KW] NINDS, Receptor Biol Sect, NIH, Bethesda, MD 20892 USA [Suh, YH Suh, YH] Ajou Univ, Sch Med, Dept Pharmacol, Grad Program Neurosci, Suwon 441749, South Korea [Tessarollo, L] NCI, Mouse Canc Genet Program, CCR, NIH, Frederick, MD 21701 USA [Yoshimoto-Furusawa, A; Mackem, S] NCI, Canc & Dev Biol Lab, CCR, NIH, Frederick, MD 21701 USA;Suh, YH (reprint author), NCI, Expt Immunol Branch, NIH, Bldg 10, Bethesda, MD 20892 USA;paul.roche@nih.gov
    1. Year: 2011
    2. Date: Mar
  2. Journal: Plos One
    1. 6
    2. 3
    3. Pages: 7
  4. Type of Article: Article
  5. Article Number: e18444
  6. ISSN: 1932-6203
  1. Abstract:

    SNARE-mediated membrane fusion is a pivotal event for a wide-variety of biological processes. SNAP-25, a neuron-specific SNARE protein, has been well-characterized and mouse embryos lacking Snap25 are viable. However, the phenotype of mice lacking SNAP-23, the ubiquitously expressed SNAP-25 homolog, remains unknown. To reveal the importance of SNAP-23 function in mouse development, we generated Snap23-null mice by homologous recombination. We were unable to obtain newborn SNAP-23-deficient mice, and analysis of pre-implantation embryos from Snap23(Delta/wt) matings revealed that Snap23-null blastocysts were dying prior to implantation at embryonic day E3.5. Thus these data reveal a critical role for SNAP-23 during embryogenesis.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1371/journal.pone.0018444
  3. View record in Web of Science®
  4. WOS: 000289054600052

Library Notes

  1. Fiscal Year: FY2010-2011
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel