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Human Leukocyte Antigen Class I Region Single-Nucleotide Polymorphisms are Associated with Leprosy Susceptibility in Vietnam and India

  1. Author:
    Alter, A.
    Huong, N. T.
    Singh, M.
    Orlova, M.
    Thuc, N. V.
    Katoch, K.
    Gao, X. J.
    Thai, V. H.
    Ba, N. N.
    Carrington, M.
    Abel, L.
    Mehra, N.
    Alcais, A.
    Schurr, E.

  2. Author Address

    [Alter, A; Orlova, M; Schurr, E] McGill Univ, McGill Ctr Study Host Resistance, Dept Med, Res Inst,Hlth Ctr, Montreal, PQ, Canada [Huong, NT; Thuc, NV; Thai, VH; Ba, NN] Hosp Dermatovenereol, Thanh Pho Ho Chi Minh, Vietnam [Singh, M; Mehra, N] All India Inst Med Sci, Dept Transplant Immunol & Immunogenet, New Delhi, India [Katoch, K] Cent JALMA Inst Leprosy & Other Infect Dis, Agra, Uttar Pradesh, India [Gao, XJ; Carrington, M] NCI Frederick, Expt Immunol Lab, SAIC Frederick Inc, Frederick, MD USA [Carrington, M] MGH MIT & Harvard Univ, Ragon Inst, Boston, MA USA [Abel, L; Alcais, A] Univ Paris 05, Fac Med Necker, Paris, France [Abel, L] Rockefeller Univ, Rockefeller Branch, Lab Human Genet Infect Dis, New York, NY 10021 USA [Alter, A; Orlova, M; Schurr, E] McGill Univ, McGill Ctr Study Host Resistance, Dept Human Genet, Res Inst,Hlth Ctr, Montreal, PQ, Canada [Abel, L; Alcais, A] INSERM, U550, Lab Genet Malad Infect, F-75654 Paris 13, France;Schurr, E (reprint author), Montreal Gen Hosp, Res Inst, 1650 Cedar Ave,Room L11-521, Montreal, PQ H3G 1A4, Canada;erwin.schurr@mcgill.ca
    1. Year: 2011
    2. Date: May
  2. Journal: Journal of Infectious Diseases
    1. 203
    2. 9
    3. Pages: 1274-1281
  4. Type of Article: Article
  5. ISSN: 1537-6613
  1. Abstract:

    Experimental evidence suggested the existence of unidentified leprosy susceptibility loci in the human leukocyte antigen (HLA) complex. To identify such genetic risk factors, a high-density association scan of a 1.9-mega-base (Mb) region in the HLA complex was performed. Among 682 single-nucleotide polymorphisms (SNPs), 59 were associated with leprosy (P <.01) in 198 Vietnamese single-case leprosy families. Genotyping of these SNPs in an independent sample of 292 Vietnamese single-case leprosy families replicated the association of 12 SNPs (P <.01). Multivariate analysis of these 12 SNPs showed that the association information could be captured by 2 intergenic HLA class I region SNPs (P = 9.4 x 10(-9))-rs2394885 and rs2922997 (marginal multivariate P = 2.1 x 10(-7) and P = .0016, respectively). SNP rs2394885 tagged the HLA-C*15:05 allele in the Vietnamese population. The identical associations were validated in a third sample of 364 patients with leprosy and 371 control subjects from North India. These results implicated class I alleles in leprosy pathogenesis.

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External Sources

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  2. DOI: 10.1093/infdis/jir024
  3. View record in Web of Science®
  4. WOS: 000289306100011

Library Notes

  1. Fiscal Year: FY2010-2011

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