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Synthesis of Fused Bicyclic Systems with Nitrogen Atom at the Bridgehead, Including Indolizidines and Quinolizidines

  1. Author:
    Pepe, A.
    Pamment, M.
    Georg, G. I.
    Malhotra, S. V.

  2. Author Address

    [Pepe, A; Georg, GI] Univ Minnesota, Dept Med Chem, Minneapolis, MN 55414 USA [Pepe, A; Georg, GI] Univ Minnesota, Inst Therapeut Discovery & Dev, Minneapolis, MN 55414 USA [Pepe, A; Pamment, M; Malhotra, SV] NCI, Lab Synthet Chem, SAIC Frederick Inc, Frederick, MD 21702 USA;Georg, GI (reprint author), Univ Minnesota, Dept Med Chem, 717 Delaware St SE, Minneapolis, MN 55414 USA;georg@umn.edu malhotrasa@mail.nih.gov
    1. Year: 2011
    2. Date: May
  2. Journal: Journal of Organic Chemistry
    1. 76
    2. 9
    3. Pages: 3527-3530
  4. Type of Article: Article
  5. ISSN: 0022-3263
  1. Abstract:

    Monocyclic as well as fused bicyclic systems with a nitrogen 10 atom at the bridgehead, including indolizidines and quinolizidines, can be prepared in four steps from N-Boc beta-lactams. These easily prepared, highly robust, and flexible building blocks allow the incorporation of chirality and structural diversity, rendering the method feasible for diversity- as well as target-oriented synthesis.

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External Sources

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  2. DOI: 10.1021/jo102558u
  3. View record in Web of Science®
  4. WOS: 000289956900063

Library Notes

  1. Fiscal Year: FY2010-2011
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