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Craf-1 Protein Kinase Is Essential For Mouse Development

  1. Author:
    Wojnowski, L.
    Stancato, L. F.
    Zimmer, A. M.
    Hahn, H.
    Beck, T. W.
    Larner, A. C.
    Rapp, U. R.
    Zimmer, A.

  2. Author Address

    Zimmer A NIMH GENET SECT 36 CONVENT DR 3D06 BETHESDA, MD 20892 USA NIMH GENET SECT BETHESDA, MD 20892 USA US FDA CTR BIOL EVALUAT & RES DIV CYTOKINE BIOL BETHESDA, MD 20892 USA NCI INTRAMURAL RES SUPPORT PROGRAM SAIC FREDERICK FREDERICK CANC RES & DEV CTR FREDERICK, MD USA UNIV WURZBURG INST MED STRAHLENKUNDE & ZELLFORSCH WURZBURG GERMANY
    1. Year: 1998
  2. Journal: Mechanisms of Development
    1. 76
    2. 1-2
    3. Pages: 141-149
  4. Type of Article: Article
  1. Abstract:

    The three mammalian Raf serine/threonine protein kinases mediate the transduction of proliferative and differentiative signals from a variety of cell surface receptors to the nucleus. We report here that Craf-1 is essential for mouse development, as its mutation results in embryonic lethality. Developmental defects are: found in mutant placentas as well as in the skin and in the lungs of mutant embryos. Craf-1 mutants also display a generalized growth retardation which is consistent with the ubiquitous expression of Craf-1 and which could be due to the reduced proliferation of mutant cells. Interestingly, the time-point of embryonal death varies depending on the genetic background. This suggests that Craf-1-mediated signaling is affected by genetic background-specific alleles of other genes. (C) 1998 Elsevier Science Inland Ltd. All rights reserved. [References: 30]

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