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Modifications of Glycans: Biological Significance and Therapeutic Opportunities

  1. Author:
    Muthana, S. M.
    Campbell, C. T.
    Gildersleeve, J. C.

  2. Author Address

    [Muthana, Saddam M.; Campbell, Christopher T.; Gildersleeve, Jeffrey C.] NCI, Biol Chem Lab, Frederick, MD 21702 USA.;Gildersleeve, JC (reprint author), NCI, Biol Chem Lab, Frederick, MD 21702 USA;gildersj@mail.nih.gov
    1. Year: 2012
    2. Date: Jan
  2. Journal: Acs Chemical Biology
    1. 7
    2. 1
    3. Pages: 31-43
  4. Type of Article: Article
  5. ISSN: 1554-8929
  1. Abstract:

    Carbohydrates play a central role in a wide range of biological processes. As with nucleic acids and proteins, modifications of specific sites within the glycan chain can modulate a carbohydrate's overall biological function. For example, acylation, methylation, sulfation, epimerization, and phosphorylation can occur at various positions within a carbohydrate to modulate bioactivity. Therefore, there is significant interest in identifying discrete carbohydrate modifications and understanding,their biological effects. Additionally, enzymes that catalyze those modifications and proteins that bind modified glycans provide numerous targets for therapeutic intervention. This review will focus on modifications of glycans that occur after the oligomer/polymer has been assembled, generally referred to as post-glycosylational modifications.

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External Sources

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  2. DOI: 10.1021/cb2004466
  3. View record in Web of Science®
  4. WOS: 000299241300005

Library Notes

  1. Fiscal Year: FY2011-2012
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