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Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site

  1. Author:
    Sarafianos, S. G.
    Das, K.
    Ding, J. P.
    Boyer, P. L.
    Hughes, S. H.
    Arnold, E.

  2. Author Address

    Arnold E Rutgers State Univ, Ctr Adv Biotechnol & Med 679 Hoes Lane Piscataway, NJ 08854 USA Rutgers State Univ, Ctr Adv Biotechnol & Med Piscataway, NJ 08854 USA Rutgers State Univ, Dept Chem Piscataway, NJ 08854 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Chemistry & Biology
    1. 6
    2. 5
    3. Pages: R137-R146
  4. Type of Article: Article
  1. Abstract:

    Comparison of the recently solved structure of HIV-1 reverse transcriptase (RT)-DNA-dNTP ternary complex with the previously solved structure of RT-DNA binary complex suggests mechanisms by which the HIV-1 RT becomes resistant to nucleoside-analog inhibitors, drugs currently used in the treatment of AIDS. [References: 68]

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