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Cytotoxic metabolites from an Australian collection of the sponge Jaspis species

  1. Author:
    Groweiss, A.
    Newcomer, J. J.
    O'Keefe, B. R.
    Blackman, A.
    Boyd, M. R.

  2. Author Address

    Boyd MR NCI, Frederick Canc Res & Dev Ctr, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diagno Bldg 1052,Room 102 Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diagno Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Journal of Natural Products
    1. 62
    2. 12
    3. Pages: 1691-1693
  4. Type of Article: Article
  1. Abstract:

    Three new natural products, bengamide Y (1), bengamide Z (3), and bengazole Z (5), were isolated from the aqueous extract of an Australian collection of the sponge Jaspis sp. Their structures were solved by spectroanalytical methods and by comparison of their spectral data with known bengamides and bengazoles that were reported from the same genus. Bengamides Y (1) and Z (3) showed a striking differential cytotoxicity pattern against a panel of 10 human tumor cell lines, with closely related cell lines (e.g., SNB-19 and SNB-75) displaying significant differences in sensitivity. [References: 23]

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