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A mechanism of resistance to HIV-1 entry: Inefficient interactions of CXCR4 with CD4 and gp120 in macrophages

  1. Author:
    Dimitrov, D. S.
    Norwood, D.
    Stantchev, T. S.
    Feng, Y. R.
    Xiao, X. D.
    Broder, C. C.

  2. Author Address

    Dimitrov DS NCI, Lab Expt & Computat Biol, DBS, FCRDC,NIH Bldg 469,Room 216,POB B,Miller Dr Frederick, MD 21702 USA NCI, Lab Expt & Computat Biol, DBS, FCRDC,NIH Frederick, MD 21702 USA Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol Bethesda, MD 20814 USA
    1. Year: 1999
  2. Journal: Virology
    1. 259
    2. 1
    3. Pages: 1-6
  4. Type of Article: Article
  1. Abstract:

    To test the hypothesis that inefficient interactions of CXCR4 with CD4 and gp120 could affect HIV-1 entry, we incubated macrophages, monocytes, and lymphocytes with gp120 and coimmunoprecipitated CD4 by using anti-CXCR4 antibodies. CD4 was efficiently coimmunoprecipitated in lymphocytes and monocytes but not in macrophages. Overexpression of CD4 in macrophages resulted in detection of CD4-CXCR4 and gp120-CD4-CXCR4 complexes in parallel with the restoration of macrophage fusion susceptibility. These results suggest a mechanism of resistance to entry of some X4 HIV-1 strains into macrophages and a method for dissection of the initial stages of HIV entry. [References: 38]

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