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IL4 from T Follicular Helper Cells Downregulates Antitumor Immunity

  1. Author:
    Shirota, Hidekazu
    Klinman, Dennis
    Ito, Shuku-ei
    Ito, Hiroyasu
    Kubo, Masato
    Ishioka, Chikashi

  2. Author Address

    Tohoku Univ Hosp, Dept Clin Oncol, Sendai, Miyagi, Japan.NCI, Canc & Inflammat Program, Frederick, MD 21701 USA.Gifu Univ, Dept Informat Clin Med, Grad Sch Med, Gifu, Japan.Tokyo Univ Sci, Res Inst Biol Sci, Div Mol Pathol, Chiba, Japan.
    1. Year: 2017
    2. Date: Jan
  2. Journal: CANCER IMMUNOLOGY RESEARCH
  3. AMER ASSOC CANCER RESEARCH,
    1. 5
    2. 1
    3. Pages: 61-71
  5. Type of Article: Article
  6. ISSN: 2326-6066
  1. Abstract:

    Immune cells constitute a large fraction of the tumor microenvironment and modulate tumor progression. Clinical data indicate that chronic inflammation is present at tumor sites and that IL4 in particular is upregulated. Here, we demonstrate that T follicular helper (Tfh) cells arise in tumor-draining lymph nodes where they produce an abundance of IL4. Deletion of IL4-expressing Tfh cells improves antitumor immunity, delays tumor growth, and reduces the generation of immunosuppressive myeloid cells in the lymph nodes. These findings suggest that IL4 from Tfh cells affects antitumor immunity and constitutes an attractive therapeutic target to reduce immunosuppression in the tumor microenvironment, and thus enhance the efficacy of cancer immunotherapy. Cancer Immunol Res; (C) 2016 AACR.

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External Sources

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  2. DOI: 10.1158/2326-6066.CIR-16-0113
  3. PMID: 27920023
  4. View record in Web of Science®
  5. WOS: 000392240600007

Library Notes

  1. Fiscal Year: FY2016-2017
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