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Circulating Cell-free DNA for Metastatic Cervical Cancer Detection, Genotyping, and Monitoring

  1. Author:
    Kang, Zhigang
    Stevanovic, Sanja
    Hinrichs, Christian S.
    Cao, Liang

  2. Author Address

    NCI, Genet Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.Leidos Biomed Res Inc, Basic Sci Program, Frederick, MD USA.NCI, Expt Transplantat & Immunol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
    1. Year: 2017
    2. Date: NOV 15
  2. Journal: CLINICAL CANCER RESEARCH
  3. AMER ASSOC CANCER RESEARCH,
    1. 23
    2. 22
    3. Pages: 6856-6862
  5. Type of Article: Article
  6. ISSN: 1078-0432
  1. Abstract:

    Purpose: Circulating cell-free (ccf) human papillomavirus (HPV) DNA may serve as a unique tumor marker for HPV-associated malignancies, including cervical cancer. We developed a method to genotype and quantify circulating HPV DNA in patients with HPV16- or HPV18-positive metastatic cervical cancer for potential disease monitoring and treatment-related decision making.

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External Sources

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  2. DOI: 10.1158/1078-0432.CCR-17-1553
  3. PMID: 28899967
  4. View record in Web of Science®
  5. WOS: 000415111900011

Library Notes

  1. Fiscal Year: FY2017-2018
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