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A lipid-based cell penetrating nano-assembly for RNAi-mediated anti-angiogenic cancer therapy

  1. Author:
    Majumder, Poulami
    Bhunia, Sukanya
    Chaudhuri, Arabinda

  2. Author Address

    CSIR Indian Inst Chem Technol, Dept Chem Biol, Hyderabad 500007, Andhra Pradesh, India.AcSIR, 2 Rafi Marg, New Delhi, India.NCI, Biol Chem Lab, 376 Boyles St, Frederick, MD 21702 USA.Univ Texas Southwestern Med Ctr Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
    1. Year: 2018
    2. Date: FEB 11
  2. Journal: CHEMICAL COMMUNICATIONS
  3. ROYAL SOC CHEMISTRY,
    1. 54
    2. 12
    3. Pages: 1489-1492
  5. Type of Article: Article
  6. ISSN: 1359-7345
  1. Abstract:

    Limited tumor tissue penetration is one of the key impeding factors retarding successful in vivo exploitations of anti-angiogenic cancer therapy. Herein we report on the design of a cell penetrating peptide-decorated lipid nano-assembly which, upon systemic administration, induces significant mouse tumor growth inhibition via enhanced tumor infiltration of encapsulated anti-angiogenic siRNA.

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External Sources

  1. View Full Text
  2. DOI: 10.1039/c7cc08517f
  3. PMID: 2935976
  4. View record in Web of Science®
  5. WOS: 000424224800021

Library Notes

  1. Fiscal Year: FY2017-2018
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