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Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21

  1. Author:
    Ostrom, Quinn T.
    Kinnersley, Ben
    Wrensch, Margaret R.
    Eckel-Passow, Jeanette E.
    Armstrong, Georgina
    Rice, Terri
    Chen, Yanwen
    Wiencke, John K.
    McCoy, Lucie S.
    Hansen, Helen M.
    Amos, Christopher I.
    Bernstein, Jonine L.
    Claus, Elizabeth B.
    Il'yasova, Dora
    Johansen, Christoffer
    Lachance, Daniel H.
    Lai, Rose K.
    Merrell, Ryan T.
    Olson, Sara H.
    Sadetzki, Siegal
    Schildkraut, Joellen M.
    Shete, Sanjay
    Rubin, Joshua B.
    Lathia, Justin D.
    Berens, Michael E.
    Andersson, Ulrika
    Rajaraman, Preetha
    Chanock, Stephen
    Linet, Martha
    Wang, Zhaoming
    Yeager, Meredith
    Houlston, Richard S.
    Jenkins, Robert B.
    Melin, Beatrice
    Bondy, Melissa L.
    Barnholtz-Sloan, Jill. S.

  2. Author Address

    Baylor Coll Med, Dept Med, Sect Epidemiol & Populat Sci, Dan L Duncan Comprehens Canc Ctr, Houston, TX 77030 USA.Case Western Reserve Univ, Sch Med, Case Comprehens Canc Ctr, Cleveland, OH USA.Case Western Reserve Univ, Sch Med, Dept Populat & Quantitat Heath Sci, Cleveland, OH USA.Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England.Univ Calif San Francisco, Sch Med, Dept Neurol Surg, San Francisco, CA 94143 USA.Univ Calif San Francisco, Sch Med, Inst Human Genet, San Francisco, CA USA.Mayo Clin Coll Med, Div Biomed Stat & Informat, Rochester, MN USA.Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Inst Clin & Translat Res, Houston, TX USA.Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.Yale Univ, Sch Publ Hlth, New Haven, CT USA.Brigham & Womens Hosp, Dept Neurosurg, Boston, MA USA.Georgia State Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Atlanta, GA USA.Duke Univ, Med Ctr, Dept Community & Family Med, Canc Control & Prevent Program, Durham, NC USA.Duke Univ, Med Ctr, Duke Canc Inst, Durham, NC USA.Rigshosp, Finsen Ctr, Oncol Clin, Copenhagen, Denmark.Danish Canc Soc Res Ctr, Survivorship Res Unit, Copenhagen, Denmark.Mayo Clin, Comprehens Canc Ctr, Dept Neurol, Rochester, MN USA.Univ Southern Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA.Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.NorthShore Univ HealthSyst, Dept Neurol, Evanston, IL USA.Chaim Sheba Med Ctr, Gertner Inst, Canc & Radiat Epidemiol Unit, Tel Hashomer, Israel.Tel Aviv Univ, Sackler Fac Med, Sch Publ Hlth, Dept Epidemiol & Prevent Med, Tel Aviv, Israel.Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA.Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX USA.Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.Washington Univ, Sch Med, Dept Neurosci, St Louis, MO USA.Cleveland Clin Fdn, Dept Stem Cell Biol & Regenerat Med, Cleveland, OH USA.Translat Genom Res Inst, Canc & Cell Biol Div, Phoenix, AZ USA.Umea Univ, Fac Med, Dept Radiat Sci, Umea, Sweden.NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.SAIC Frederick Inc, NCI, Core Genotyping Facil, Gaithersburg, MD USA.Mayo Clin, Comprehens Canc Ctr, Dept Lab Med & Pathol, Rochester, MN USA.
    1. Year: 2018
    2. Date: May 9
  2. Journal: Scientific Reports
  3. NATURE PUBLISHING GROUP,
    1. 8
    2. 1
    3. Pages: 7352
  5. Type of Article: Article
  6. Article Number: ARTN 7352
  7. ISSN: 2045-2322
  1. Abstract:

    Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.

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External Sources

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  2. DOI: 10.1038/s41598-018-24580-z
  3. PMID: 29743610
  4. PMCID: PMC5943590
  5. View record in Web of Science®
  6. WOS: 000431737300038

Library Notes

  1. Fiscal Year: FY2017-2018
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