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Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

  1. Author:
    Chacon-Duque, Juan-Camilo
    Adhikari, Kaustubh
    Fuentes-Guajardo, Macarena
    Mendoza-Revilla, Javier
    Acuna-Alonzo, Victor
    Barquera, Rodrigo
    Quinto-Sanchez, Mirsha
    Gomez-Valdes, Jorge
    Everardo Martinez, Paola
    Villamil-Ramirez, Hugo
    Hunemeier, Tabita
    Ramallo, Virginia
    Silva de Cerqueira, Caio C.
    Hurtado, Malena
    Villegas, Valeria
    Granja, Vanessa
    Villena, Mercedes
    Vasquez, Rene
    Llop, Elena
    Sandoval, Jose R.
    Salazar-Granara, Alberto A.
    Parolin, Maria-Laura
    Sandoval, Karla
    Penaloza-Espinosa, Rosenda I.
    Rangel-Villalobos, Hector
    Winkler, Cheryl
    Klitz, William
    Bravi, Claudio
    Molina, Julio
    Corach, Daniel
    Barrantes, Ramiro
    Gomes, Veronica
    Resende, Carlos
    Gusmao, Leonor
    Amorim, Antonio
    Xue, Yali
    Dugoujon, Jean-Michel
    Moral, Pedro
    Gonzalez-Jose, Rolando
    Schuler-Faccini, Lavinia
    Salzano, Francisco M.
    Bortolini, Maria-Catira
    Canizales-Quinteros, Samuel
    Poletti, Giovanni
    Gallo, Carla
    Bedoya, Gabriel
    Rothhammer, Francisco
    Balding, David
    Hellenthal, Garrett
    Ruiz-Linares, Andres

  2. Author Address

    UCL, Dept Genet Evolut & Environm, London WC1E 6BT, England.UCL, Genet Inst, London WC1E 6BT, England.Univ Tarapaca, Fac Ciencias Salud, Dept Tecnol Med, Arica 1000009, Chile.Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Labs Invest & Desarrollo, Lima 31, Peru.Escuela Nacl Antropol & Hist, Mol Genet Lab, Mexico City 14030, DF, Mexico.Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.Univ Nacl Autonoma Mexico, Fac Med, Ciencia Forense, Mexico City 04510, DF, Mexico.Escuela Nacl Antropol & Hist, Posgrad Antropol Fis, Mexico City 14030, DF, Mexico.Univ Nacl Autonoma Mexico, Posgrad Antropol, Mexico City 04510, DF, Mexico.Univ Nacl Autonoma Mexico, Fac Quim, Unidad Genom Poblac Aplicada Salud, Mexico City 04510, DF, Mexico.Inst Nacl Med Genom, Mexico City 04510, DF, Mexico.Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, BR-05508090 Sao Paulo, Brazil.Consejo Nacl Invest Cient & Tecn, Inst Patagon Ciencias Sociales & Humanas, Ctr Nacl Patagon, U912OACD, Puerto Madry, Argentina.Univ Fed Rio Grande do Sul, Dept Genet, BR-91501970 Porto Alegre, RS, Brazil.Univ Mayor San Andres, IBBA, La Paz 2070, Bolivia.Univ Autonoma Tomas Frias, IBBA, Potosi 53820, Bolivia.Univ Chile, Fac Med, ICBM, Programa Genet Humana, Santiago 1027, Chile.Univ San Martin Porres, Fac Med Humana, Lima 12, Peru.Consejo Nacl Invest Cient & Tecn, Ctr Nacl Patagon, Inst Diversidad & Evoluc Austral IDEAus, Puerto Madryn, Argentina.CINVESTAV, Natl Lab Genom & Biodivers LANGEBIO, Irapuato 36821, Mexico.Univ Autonoma Metropolitana Xochimilco, Div Biol & Hlth Sci, Dept Biol Syst, Mexico City 04960, DF, Mexico.Univ Guadalajara, Inst Invest Genet Mol, Ocotlan 1115, Mexico.NCI, Basic Res Lab, Frederick Natl Lab, Frederick, MD 21702 USA.Univ Calif Berkeley, Integrat Biol, Berkeley, CA 94720 USA.Consejo Nacl Invest Cient & Tecn, Inst Multidisciplinario Biol Celular, B1906APO, La Plata, Buenos Aires, Argentina.Ctr Invest Biomed Guatemala, Guatemala City 01011, Guatemala.Univ Buenos Aires, Serv Huellas Digitales Genet, C1113AAD, Buenos Aires, DF, Argentina.Univ Buenos Aires, CONICET, C1113AAD, Buenos Aires, DF, Argentina.Univ Costa Rica, Escuela Biol, San Jose 2060, Costa Rica.Univ Porto IPATIMUP, Inst Patol & Imunol Mol, P-4200135 Porto, Portugal.Univ Porto, Inst Invest & Inovacao Saude i3S, P-4200135 Porto, Portugal.Univ Estado Rio de Janeiro, DNA Diagnost Lab LDD, BR-23968000 Rio De Janeiro, Brazil.Univ Porto, Fac Ciencias, P-4169007 Porto, Portugal.Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England.Univ Toulouse Paul Sabatier, CNRS, F-31330 Toulouse, France.Univ Barcelona, Dept Biol Evolut Ecol & Ciencias Ambientales, E-08007 Barcelona, Spain.Univ Antioquia, Genet Mol GENMOL, Medellin 5001000, Colombia.Univ Tarapaca, Inst Alta Invest, Arica 1000009, Chile.Univ Melbourne, Sch BioSci, Melbourne, Vic 3010, Australia.Univ Melbourne, Sch Math & Stat, Melbourne, Vic 3010, Australia.Fudan Univ, Sch Life Sci, Key Lab Contemporary Anthropol, Minist Educ, Shanghai 200433, Peoples R China.Fudan Univ, Sch Life Sci, Collaborat Innovat Ctr Genet & Dev, Shanghai 200433, Peoples R China.Fudan Univ, Human Phenome Inst, Shanghai 200433, Peoples R China.Aix Marseille Univ, CNRS, EFS, ADES, F-13007 Marseille, France.Sci Police Sao Paulo State, BR-19900109 Ourinhos, SP, Brazil.
    1. Year: 2018
    2. Date: Dec 19
    3. Epub Date: 2018 12 19
  2. Journal: Nature communications
  3. NATURE PUBLISHING GROUP,
    1. 9
    2. 1
  5. Type of Article: Article
  6. Article Number: 5388
  7. ISSN: 2041-1723
  1. Abstract:

    Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.

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External Sources

  1. View Full Text
  2. DOI: 10.1038/s41467-018-07748-z
  3. PMID: 30568240
  4. PMCID: PMC6300600
  5. View record in Web of Science®
  6. WOS: 000453754200011

Library Notes

  1. Fiscal Year: FY2018-2019
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