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Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective

  1. Author:
    Basudhar,Debashree
    Bharadwaj, Gaurav
    Somasundaram,Veena
    Cheng,Robert
    Ridnour,Lisa
    Fujita, Mayumi
    Lockett,Stephen
    Anderson,Steve
    McVicar,Daniel
    Wink,David

  2. Author Address

    NCI, Canc & Inflammat Program, Ctr Canc Res, NIH, Bldg 567,Rm 254,1050 Boyles St, Frederick, MD 21702 USA.Natl Inst Quantum & Radiol Sci & Technol, Natl Inst Radiol Sci, Dept Basic Med Sci Radiat Damages, Chiba, Chiba, Japan.NCI, Opt Microscopy & Anal Lab, Frederick Natl Lab Canc Res, Leidos Biomed Res Inc,NIH, Frederick, MD 21701 USA.
    1. Year: 2019
    2. Date: Jan
    3. Epub Date: 2018 08 28
  2. Journal: British Journal of Pharmacology
  3. WILEY,
    1. 176
    2. 2
    3. Pages: 155-176
  5. Type of Article: Review
  6. ISSN: 0007-1188
  1. Abstract:

    Recent findings suggest that co-expression of NOS2 and COX2 is a strong prognostic indicator in triple-negative breast cancer patients. These two key inflammation-associated enzymes are responsible for the biosynthesis of NO and PGE(2), respectively, and can exert their effect in both an autocrine and paracrine manner. Impairment of their physiological regulation leads to critical changes in both intra-tumoural and intercellular communication with the immune system and their adaptation to the hypoxic tumour micro-environment. Recent studies have also established a key role of NOS2-COX2 in causing metabolic shift. This review provides an extensive overview of the role of NO and PGE(2) in shaping communication between the tumour micro-environment composed of tumour and immune cells that in turn favours tumour progression and metastasis.

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External Sources

  1. View Full Text
  2. DOI: 10.1111/bph.14488
  3. PMID: 30152521
  4. PMCID: PMC6295414
  5. View record in Web of Science®
  6. WOS: 000453532400004

Library Notes

  1. Fiscal Year: FY2018-2019
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