Skip NavigationSkip to Content
Return Return to Search Results

Inhibition of P-glycoprotein activity and reversal of multidrug resistance in vitro by rosemary extract

  1. Author:
    Plouzek, C. A.
    Ciolino, H. P.
    Clarke, R.
    Yeh, G. C.

  2. Author Address

    Yeh GC NCI, Frederick Canc Res & Dev Ctr, Cellular Def & Carcinogenesis Sect, Div Basic Sci,Basic Res Lab,NIH Frederick, MD 21701 USA NCI, Frederick Canc Res & Dev Ctr, Cellular Def & Carcinogenesis Sect, Div Basic Sci,Basic Res Lab,NIH Frederick, MD 21701 USA Georgetown Univ, Med Ctr, Lombardi Canc Ctr Washington, DC 20007 USA
    1. Year: 1999
  2. Journal: European Journal of Cancer
    1. 35
    2. 10
    3. Pages: 1541-1545
  4. Type of Article: Article
  1. Abstract:

    The transmembrane transport pump P-glycoprotein (Pgp) causes the efflux of chemotherapeutic agents from cells and is believed to be an important mechanism in multidrug resistance (MDR) in mammary tumours. In the present study we demonstrate that an extract of the common dietary herb rosemary (Rosemarinus officinalis Labiatae), increases the intracellular accumulation of commonly used chemotherapeutic agents, including doxorubicin (DOX) and vinblastine (VIN), in drug-resistant MCF-7 human breast cancer cells which express Pgp. Rosemary extract (RE) inhibits the efflux of DOX and VIN, which are known to be substrates of Pgp, but does not affect accumulation or efflux of DOX in wild type MCF-7 cells, which lack Pgp. Treatment of drug-resistant cells with RE increases their sensitivity to DOX, which is consistent with an increased intracellular accumulation of the drug. RE blocks the binding of the VIN analogue azidopine to Pgp. Thus, it appears that RE directly inhibits Pgp activity by inhibiting the binding of drugs to Pgp. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 19]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel