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A Phase I Dose-Escalation Trial of BN-CV301, a Recombinant Poxviral Vaccine Targeting MUC1 and CEA with Costimulatory Molecules

  1. Author:
    Gatti-Mays, Margaret E.
    Strauss, Julius
    Donahue, Renee N.
    Palena, Claudia
    Del Rivero, Jaydira
    Redman, Jason M.
    Madan, Ravi A.
    Marte, Jennifer L.
    Cordes, Lisa M.
    Lamping, Elizabeth
    Orpia,Alanvin
    Burmeister, Andrea
    Wagner, Eva
    Navarro, Cesar Pico
    Heery, Christopher R.
    Schlom, Jeffrey
    Gulley, James L.

  2. Author Address

    NCI, Lab Tumor Immunol & Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.NCI, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA.NCI, Med Oncol Serv, NIH, Bethesda, MD 20892 USA.NCI, Genitourinary Malignancies Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.NCI, Oncol Clin Pharm, NIH, Bethesda, MD 20892 USA.Leidos Biomed Res Inc, Frederick, MD USA.Bavarian Nord GmbH, Martinsried, Germany.Bavarian Nord Inc, Morrisville, NC USA.
    1. Year: 2019
    2. Date: Aug 15
  2. Journal: CLINICAL CANCER RESEARCH
  3. AMER ASSOC CANCER RESEARCH,
    1. 25
    2. 16
    3. Pages: 4933-4944
  5. Type of Article: Article
  6. ISSN: 1078-0432
  1. Abstract:

    Purpose: BN-CV301 is a poxviral-based vaccine comprised of recombinant (rec.) modified vaccinia Ankara (MVA-BN-CV301; prime) and rec. fowlpox (FPV-CV301; boost). Like its predecessor PANVAC, BN-CV301 contains transgenes encoding tumor-associated antigens MUC1 and CEA as well as costimulatory molecules (B7.1, ICAM-1, and LFA-3). PANVAC was reengineered to make it safer and more antigenic.

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External Sources

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  2. DOI: 10.1158/1078-0432.CCR-19-0183
  3. PMID: 31110074
  4. PMCID: PMC6697621
  5. View record in Web of Science®
  6. WOS: 000481912400011

Library Notes

  1. Fiscal Year: FY2018-2019
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