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IL-18 is a potent coinducer of IL-13 in NK and T cells: A new potential role for IL-18 in modulating the immune response

  1. Author:
    Hoshino, T.
    Wiltrout, R. H.
    Young, H. A.

  2. Author Address

    Young HA NCI, Frederick Canc Res & Dev Ctr, Expt Immunol Lab, Div Basic Sci Bldg 560,Room 31-93 Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Expt Immunol Lab, Div Basic Sci Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Journal of Immunology
    1. 162
    2. 9
    3. Pages: 5070-5077
  4. Type of Article: Article
  1. Abstract:

    IL-13 and IL-4 have similar biological activities and are characteristic of cytokines expressed by Th2 cells. In contrast, IL-12 and IL-18 have been shown to be strong cofactors for Th1 cell development. In this study, we found strong induction of IL-13 mRNA and protein by IL-2 + IL-18 in NK and T cells, In contrast, IL-12 did not enhance the IL-13 production induced by IL-2 alone. Moreover, IL-13 mRNA and protein expression induced by IL-2 + IL-18 in purified NK and T cells obtained from IFN-gamma knockout (-/-) mice were greater than seen in purified cells from normal controls. In contrast, IL-IB production induced by IL-2 and/or IL-12 was not significantly different in IFN-gamma (-/-) mice and normal controls, These results suggest IL-13 expression induced by IL-2 + IL-18 may. be regulated by IFN-gamma in vivo, while IL-IO expression may be IFN-gamma-independent. Thus, depending upon the cell type. IL-18 may act as a strong coinducer of Th1 or Th2 cytokines. Our findings suggest that IL-12 and IL-18 have different roles in the regulation of gene expression in NK and T cells. [References: 40]

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