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The gift of a lifetime: analysis of HIV at autopsy

  1. Author:
    Maldarelli,Frank

  2. Author Address

    NCI, HIV Dynam & Replicat Program, NIH, Ft Detrick, MD USA.
    1. Year: 2020
    2. Date: Apr 1
  2. Journal: JOURNAL OF CLINICAL INVESTIGATION
  3. AMER SOC CLINICAL INVESTIGATION INC,
    1. 130
    2. 4
    3. Pages: 1611-1614
  5. Type of Article: Article
  6. ISSN: 0021-9738
  1. Abstract:

    Currently, the incidence of HIV infection exceeds the death rate from HIV, and as a result, the prevalence of individuals living with the infection continues to increase. A critical limitation preventing the development of curative strategies is the lack of knowledge regarding mechanisms that allow HIV-infected cells to persist in individuals during combination antiviral therapy (ART). In this issue of the JCI, Chaillon and coworkers assessed HIV-infected cells from various anatomic compartments obtained through a rapid autopsy program of individuals undergoing long-term ART. This study, made possible with strong community collaboration, provides new insights on the potential locations of reservoirs of HIV-infected cells that persist during therapy.

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External Sources

  1. View Full Text
  2. DOI: 10.1172/JCI135905
  3. PMID: 32091411
  4. PMCID: PMC7108884
  5. View record in Web of Science®
  6. WOS: 000530101000010

Library Notes

  1. Fiscal Year: FY2019-2020
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