Skip NavigationSkip to Content
Return Return to Search Results

Chemical Modulation of Pre-mRNA Splicing in Mammalian Systems

  1. Author:
    Boer, Robert E.
    Torrey, Zachary R.
    Schneekloth,Jay

  2. Author Address

    NCI, Chem Biol Lab, Frederick, MD 21702 USA.
    1. Year: 2020
    2. Date: Apr 17
  2. Journal: ACS CHEMICAL BIOLOGY
  3. AMER CHEMICAL SOC,
    1. 15
    2. 4
    3. Pages: 808-818
  5. Type of Article: Article
  6. ISSN: 1554-8929
  1. Abstract:

    RNA splicing is a key component of gene expression and proteomic diversity in humans. The spliceosome assembles on and processes individual nascent pre-mRNA transcripts into distinct mature mRNAs that can code for different proteins. Splicing programs can be affected by somatic mutations and changes in response to exogenous stimuli. Importantly, alterations in splicing can be direct drivers of diseases including cancers. This Review describes recent advances and the potential for targeting and controlling pre-mRNA splicing in humans with small molecules, ranging from targeting spliceosomal proteins to direct targeting of individual RNA transcripts.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1021/acschembio.0c00001
  3. PMID: 32191432
  4. View record in Web of Science®
  5. WOS: 000526890700002

Library Notes

  1. Fiscal Year: FY2019-2020
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel