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Sinularamides A-G, Terpenoid-Derived Spermidine and Spermine Conjugates with Casitas B-Lineage Lymphoma Proto-Oncogene B (CbI-b) Inhibitory Activities from a Sinularia sp. Soft Coral

  1. Author:
    Jiang, Wei
    Wang,Dongdong
    Wilson,Brice
    Voeller, Donna
    Bokesch, Heidi R.
    Smith,Emily
    Lipkowitz, Stanley
    O'Keefe,Barry
    Gustafson,Kirk

  2. Author Address

    Yangzhou Univ, Coll Environm Sci & Engn, Marine Sci & Technol Inst, Yangzhou 225127, Jiangsu, Peoples R China.NCI, Mol Targets Program, Ctr Canc Res, Frederick, MD 21702 USA.NCI, Womens Malignancy Branch, Ctr Canc Res, Bethesda, MD 20892 USA.Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Basic Sci Program, Frederick, MD 21702 USA.NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Frederick, MD 21701 USA.
    1. Year: 2021
    2. Date: Jun 25
    3. Epub Date: 2021 05 26
  2. Journal: Journal of natural products
  3. AMER CHEMICAL SOC,
    1. 84
    2. 6
    3. Pages: 1831-1837
  5. Type of Article: Article
  6. ISSN: 0163-3864
  1. Abstract:

    An extract of a Sinularia sp. soft coral showed inhibitory activity against the E3-ubiquitin ligase casitas B-lineage lymphoma proto-oncogene B (Cbl-b). Subsequent bioassay-guided separation of the extract provided a series of terpenoid-derived spermidine and spermine amides that were named sinularamides A-G (1-7). Compounds 1-7 represent new natural products; however, sinularamide A (1) was previously reported as a synthetic end product. The structures of sinularamides A-G (1-7) were elucidated by analysis of spectroscopic and spectrometric data from NMR, IR, and HRESIMS experiments and by comparison with literature data. All of the isolated compounds showed Cbl-b inhibitory activities with IC50 values that ranged from approximately 6.5 to 33 mu M.

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External Sources

  1. View Full Text
  2. DOI: 10.1021/acs.jnatprod.1c00367
  3. PMID: 34038132
  4. View record in Web of Science®
  5. WOS: 000668368800015

Library Notes

  1. Fiscal Year: FY2020-2021
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