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Joint Associations of Maternal-Fetal APOL1 Genotypes and Maternal Country of Origin With Preeclampsia Risk

  1. Author:
    Hong, Xiumei
    Rosenberg, Avi Z.
    Zhang, Boyang
    Binns-Roemer,Elizabeth
    David,Victor
    Lv, Yiming
    Hjorten, Rebecca C.
    Reidy, Kimberly J.
    Chen, Teresa K.
    Wang, Guoying
    Ji, Yuelong
    Simpson, Claire L.
    Davis, Robert L.
    Kopp, Jeffrey B.
    Wang, Xiaobin
    Winkler,Cheryl

  2. Author Address

    Johns Hopkins Univ, Dept Populat Family & Reprod Hlth, Ctr Early Life Origins Dis, Bloomberg Sch Publ Hlth, Baltimore, MD USA.Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA.Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD USA.NCI, Mol Genet Epidemiol Sect, Frederick Natl Lab Canc Res Basic Res Lab, Frederick, MD USA.NCI, Basic Res Lab, Ctr Canc Res, Frederick, MD USA.Univ WA, Dept Med, Div Nephrol, Seattle, WA USA.Albert Einstein Coll Med, Div Pediat Nephrol, Dept Pediat, Childrens Hosp Montefiore, Bronx, NY USA.Johns Hopkins Med Inst, Dept Med, Div Nephrol, Baltimore, MD USA.Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA.Univ TN Hlth Sci Ctr, Dept Genet Genom & Informat, Memphis, TN USA.Univ TN Hlth Sci Ctr, Ctr Biomed Informat, Dept Pediat, Memphis, TN USA.NIDDKD, Kidney Dis Sect, NIH, Bethesda, MD USA.Johns Hopkins Univ, Div Gen Pediat & Adolescent Med, Dept Pediat, Sch Med, Baltimore, MD USA.
    1. Year: 2021
    2. Date: Jun
  2. Journal: American Journal of Kidney Diseases : the official Journal of the National Kidney Foundation
  3. W B SAUNDERS CO-ELSEVIER INC,
    1. 77
    2. 6
    3. Pages: 879-888.e1
  5. Type of Article: Article
  6. ISSN: 0272-6386
  1. Abstract:

    Rationale & Objectives: Preeclampsia, which disproportionately affects Black women, is a leading cause of preterm delivery and risk for future hypertension and chronic kidney disease (CKD). Apolipoprotein L1 (APOL1) kidney risk alleles, common among Black individuals, contribute substantially to CKD disparities. Given the strong link between preeclampsia and CKD, we investigated whether maternal and fetal APOL1 risk alleles can jointly influence preeclampsia risk, and explored potential modifiers of the association between APOL1 and preeclampsia.

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External Sources

  1. View Full Text
  2. DOI: 10.1053/j.ajkd.2020.10.020
  3. PMID: 33359152
  4. View record in Web of Science®
  5. WOS: 000654233700008

Library Notes

  1. Fiscal Year: FY2020-2021
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