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Tumor-Associated Stromal Cellular Density as a Predictor of Recurrence and Mortality in Breast Cancer: Results from Ethnically Diverse Study Populations

  1. Author:
    Abubakar, Mustapha
    Zhang, Jing
    Ahearn, Thomas U.
    Koka, Hela
    Guo, Changyuan
    Lawrence,Scott
    Mutreja,Karun
    Figueroa, Jonine D.
    Ying, Jianming
    Lissowska, Jolanta
    Lyu, Ning
    Garcia-Closas, Montserrat
    Yang, Xiaohong Rose

  2. Author Address

    NCI, Integrat Tumor Epidemiol Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20850 USA.Chinese Acad Med Sci & Peking Union Med Coll, Dept Pathol, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing, Peoples R China.Leidos Biomed Res Inc, Mol & Digital Pathol Lab, Canc Genom Res Lab, Frederick, MD USA.Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.M Sklodowska Curie Natl Res Inst Oncol, Epidemiol Unit, Dept Canc Epidemiol, Warsaw, Poland.
    1. Year: 2021
    2. Date: Jul
  2. Journal: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
  3. AMER ASSOC CANCER RESEARCH,
    1. 30
    2. 7
    3. Pages: 1397-1407
  5. Type of Article: Article
  6. ISSN: 1055-9965
  1. Abstract:

    Purpose: Tumor-associated stroma is comprised of fibroblasts, tumor-infiltrating lymphocytes (TIL), macrophages, endothelial cells, and other cells that interactively influence tumor progression through inflammation and wound repair. Although gene-expression signatures reflecting wound repair predict breast cancer survival, it is unclear whether combined density of tumor-associated stromal cells, a morphologic proxy for inflammation and wound repair signatures on routine hematoxylin and eosin (H&E)-stained sections, is of prognostic relevance.

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External Sources

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  2. DOI: 10.1158/1055-9965.EPI-21-0055
  3. View record in Web of Science®
  4. WOS: 000675844700014

Library Notes

  1. Fiscal Year: FY2020-2021
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