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Activating Ly-49D NK receptors: expression and function in relation to ontogeny and Ly-49 inhibitor receptors

  1. Author:
    Ortaldo, J. R.
    Winkler-Pickett, R.
    Wiegand, G.

  2. Author Address

    NCI, Expt Immunol Lab, DBS, FCRDC, Bldg 560, Rm 31-93, Frederick, MD 21702 USA. NCI, Expt Immunol Lab, DBS, FCRDC, Frederick, MD 21702 USA. NCI, SAIC, FCRDC, Frederick, MD 21702 USA.
    1. Year: 2000
  2. Journal: Journal of Leukocyte Biology
    1. 68
    2. 5
    3. Pages: 748-756
  4. Type of Article: Article
  1. Abstract:

    Developmental changes in the repertoire of activating Ly-49 family members have not been examined previously. In the present study, we have examined the expression and function of the activating Ly-49s (D and H) from birth through 8 weeks of age, We demonstrate that 1) activating Ly-49s are expressed early, 2) their expression intensity is not different from adult NK cells, and 3) activating receptors are functional. Examination of the inhibitory Ly-49s also demonstrated functional capacity immediately upon expression. To examine the kinetics of expression of the repertoire of activating Ly-49 members, we utilized five- and six-color flow cytometric analyses of NK cells from birth through adulthood, Previous studies examining the inhibitory Ly-49 repertoire have proposed that expression is regulated by the product rule. Our results indicated that Ly-49D, which recognizes H-2D(d), had a discordantly high coexpression of the inhibitory Ly-49s that recognized H-2D(d) (Ly-49A and Ly-49G2). The product rule of Ly-49 expression does not explain the coexpression of selected activating and inhibitory receptors, This high level of coexpression of H-2D(d) recognizing activating and inhibitory Ly-49s suggests an in vivo selection or regulated coexpression.

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