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Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

  1. Author:
    Nguyen, Phuong H.
    Ramamoorthy, Ayyalusamy
    Sahoo, Bikash R.
    Zheng, Jie
    Faller, Peter
    Straub, John E.
    Dominguez, Laura
    Shea, Joan-Emma
    Dokholyan, Nikolay
    De Simone, Alfonso
    Ma, Buyong
    Nussinov,Ruth
    Najafi, Saeed
    Ngo, Son Tung
    Loquet, Antoine
    Chiricotto, Mara
    Ganguly, Pritam
    McCarty, James
    Li, Mai Suan
    Hall, Carol
    Wang, Yiming
    Miller, Yifat
    Melchionna, Simone
    Habenstein, Birgit
    Timr, Stepan
    Chen, Jiaxing
    Hnath, Brianna
    Strodel, Birgit
    Kayed, Rakez
    Lesne, Sylvain
    Wei, Guanghong
    Sterpone, Fabio
    Doig, Andrew J.
    Derreumaux, Philippe

  2. Author Address

    PSL Res Univ, Univ Paris, Lab Theoret Biochem, UPR9080,Fdn Edmond Rothschild,IBPS,CNRS, F-75005 Paris, France.Univ Michigan, Biophys, Ann Arbor, MI 48109 USA.Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA.Univ Akron, Dept Chem & Biomol Engn, Akron, OH 44325 USA.Univ Strasbourg, Inst Chim, UMR 7177, CNRS, F-67000 Strasbourg, France.Boston Univ, Dept Chem, 590 Commonwealth Ave, Boston, MA 02215 USA.Univ Nacl Autonoma Mexico, Fac Quim, Dept Fisicoquim, Mexico City 04510, DF, Mexico.Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA.Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA.Penn State Univ, Dept Pharmacol & Biochem & Mol Biol, Coll Med, Hershey, PA 17033 USA.Penn State Univ, Dept Chem & Biomed Engn, University Pk, PA 16802 USA.Imperial Coll London, Dept Life Sci, London SW7 2AZ, England.Univ Naples Federico II, Mol Biol, I-80138 Naples, Italy.NCI, Basic Sci Program, Leidos Biomed Res Inc, Canc & Inflammat Program, Frederick, MD 21702 USA.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai, Peoples R China.Tel Aviv Univ, Dept Human Genet & Mol Med, Sackler Inst Mol Med, Sackler Sch Med, Tel Aviv, Israel.Ton Duc Thang Univ, Lab Theoret & Computat Biophys, Ho Chi Minh City 33000, Vietnam.Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City 33000, Vietnam.Univ Bordeaux, Inst Chem & Biol Membranes & Nanoobjects, Inst Europeen Chim & Biol, UMR CBMN 5248,CNRS, F-33600 Pessac, France.Univ Manchester, Dept Chem Engn & Analyt Sci, Manchester M13 9PL, Lancs, England.Western Washington Univ, Chem Dept, Bellingham, WA 98225 USA.Inst Computat Sci & Technol, Ho Chi Minh City 700000, Vietnam.Polish Acad Sci, Inst Phys, PL-02668 Warsaw, Poland.North Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel.Ben Gurion Univ Negev, Ilse Katz Inst Nanoscale Sci & Technol, IL-84105 Beer Sheva, Israel.ISC CNR, I-00185 Rome, Italy.Forschungszentrum Julich, Inst Complex Syst Struct Biochem ICS 6, D-52425 Julich, Germany.Univ Texas Med Branch, Mitchell Ctr Neurodegenerat Dis, Galveston, TX 77555 USA.Univ Texas Med Branch, Dept Neurol, Galveston, TX 77555 USA.Univ Texas Med Branch, Dept Neurosci, Galveston, TX 77555 USA.Univ Texas Med Branch, Dept Cell Biol, Galveston, TX 77555 USA.Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA.Fudan Univ, State Key Lab Surface Phys, Dept Phys, Multiscale Res Inst Complex Syst, Shanghai 200438, Peoples R China.Fudan Univ, Key Lab Computat Phys Sci, Multiscale Res Inst Complex Syst, Shanghai 200438, Peoples R China.Univ Manchester, Div Neurosci & Expt Psychol, Sch Biol Sci, Fac Biol Med & Hlth, Manchester M13 9PT, Lancs, England.Ton Duc Thang Univ, Lab Theoret Chem, Ho Chi Minh City 33000, Vietnam.Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City 33000, Vietnam.
    1. Year: 2021
    2. Date: Feb 24
    3. Epub Date: 2021 Feb 5
  2. Journal: Chemical Reviews
  3. Amer Chemical Soc
    1. 121
    2. 4
    3. Pages: 2545-2647
  5. Type of Article: Article
  6. ISSN: 0009-2665
  1. Abstract:

    Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues. Structural and dynamic characterization of all species along the pathways from monomers to fibrils is challenging by experimental and computational means because they involve intrinsically disordered proteins in most diseases. Yet understanding how amyloid species become toxic is the challenge in developing a treatment for these diseases. Here we review what computer, in vitro, in vivo, and pharmacological experiments tell us about the accumulation and deposition of the oligomers of the (A beta, tau), alpha-synuclein, IAPP, and superoxide dismutase 1 proteins, which have been the mainstream concept underlying Alzheimer's disease (AD), Parkinson's disease (PD), type II diabetes (T2D), and amyotrophic lateral sclerosis (ALS) research, respectively, for many years.

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External Sources

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  2. DOI: 10.1021/acs.chemrev.0c01122
  3. PMID: 33543942
  4. View record in Web of Science®
  5. WOS: 000623229200012

Library Notes

  1. Fiscal Year: FY2020-2021
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