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Molecular basis for redox control by the human cystine/glutamate antiporter system xc(-)

  1. Author:
    Parker, Joanne L.
    Deme,Justin
    Kolokouris, Dimitrios
    Kuteyi, Gabriel
    Biggin, Philip C.
    Lea,Susan
    Newstead, Simon

  2. Author Address

    Univ Oxford, Dept Biochem, Oxford OX1 3QU, England.Univ Oxford, Dunn Sch Pathol, Oxford OX1 3RE, England.Univ Oxford, Cent Oxford Struct Mol Imaging Ctr, South Parks Rd, Oxford OX1 3RE, England.NCI, Ctr Struct Biol, Ctr Canc Res, Frederick, MD 21702 USA.Univ Oxford, Kavli Inst Nanosci Discovery, Oxford OX1 3QU, England.
    1. Year: 2021
    2. Date: Dec 8
  2. Journal: Nature Communications
  3. Nature Portfolio
    1. 12
    2. 1
  5. Type of Article: Article
  6. Article Number: ARTN 7147
  7. ISSN: 2041-1723
  1. Abstract:

    System xc- is a cystine transporter that is expressed in the plasma membrane and imports cystine in exchange for intracellular glutamate. Here, the authors present the cryo-EM structure of human system xc- both in the apo form and the glutamate bound state, and further supported by molecular dynamics and cell-based assays they discuss its cystine transport mechanism.

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External Sources

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  2. DOI: 10.1038/s41467-021-27414-1
  3. PMID: 34880232
  4. View record in Web of Science®
  5. WOS: 000728313100044

Library Notes

  1. Fiscal Year: FY2021-2022
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