Skip NavigationSkip to Content
Return Return to Search Results

The SeroNet Clinical and Translational Serology Task Force (CTTF) SARS-CoV-2 mucosal immunity methodological considerations and best practices workshop

  1. Author:
    Hempel,Heidi
    Mantis, Nicholas
    Heaney, Christopher D
    Pinto,Ligia

  2. Author Address

    Vaccine, Immunity and Cancer Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Wadsworth Center, New York State Department of Health, Albany, NY, USA., Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.,
    1. Year: 2023
    2. Date: Aug 01
  2. Journal: Human Vaccines & Immunotherapeutics
    1. 19
    2. 2
    3. Pages: 2253598
  4. Type of Article: Article
  5. Article Number: 2253598
  1. Abstract:

    SARS-CoV-2 persists in certain populations, even with vaccination and boosters. Emerging evidence suggests that reductions in virus transmission and infection will likely require involvement of the mucosal immune system, especially secretory antibodies in the upper respiratory tract. The Clinical and Translational Serology Task Force (CTTF) within The National Cancer Institute (NCI) 39;s Serological Sciences Network for COVID-19 (SeroNet) hosted a workshop to review the status of development and standardization of mucosal sample collection methods and assays, identify challenges, and develop action plans to bridge gaps. Speakers presented data underscoring a role for secretory IgA in protection, mucosal markers as correlates of protection, methods for tracking and assessing mucosal antibodies, and lessons learned from other infectious agents. Perspectives from regulators and industry were put forward to guide mucosal vaccine development. Methodological considerations for optimizing collection protocols and assays and harmonizing data were highlighted. Rigorous studies, standardized protocols, controls, standards, and assay validation were identified as necessary to gain momentum in expanding SARS-CoV-2 vaccines to the mucosa.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1080/21645515.2023.2253598
  3. PMID: 37695268
  4. PMCID: PMC10496519

Library Notes

  1. Fiscal Year: FY2022-2023
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel