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Antineoplastic agents 430. Isolation and structure of cribrostatins 3, 4, and 5 from the Republic of Maldives Cribrochalina species

  1. Author:
    Pettit, G. R.
    Knight, J. C.
    Collins, J. C.
    Herald, D. L.
    Pettit, R. K.
    Boyd, M. R.
    Young, V. G.

  2. Author Address

    Pettit GR Arizona State Univ, Canc Res Inst Tempe, AZ 85287 USA Arizona State Univ, Canc Res Inst Tempe, AZ 85287 USA Arizona State Univ, Dept Chem & Biochem Tempe, AZ 85287 USA NCI, Lab Drug Discovery Res & Dev, DTP, DCTD,Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA Univ Minnesota, Dept Chem Minneapolis, MN 55455 USA
    1. Year: 2000
  2. Journal: Journal of Natural Products
    1. 63
    2. 6
    3. Pages: 793-798
  4. Type of Article: Article
  1. Abstract:

    Continued investigation of cancer-cell growth-inhibitory constituents of the blue marine sponge Cribrochalina sp. has led to discovery of cribrostatins 3 (4a), 4 (5), and 5 (4b) in 10(-5) to 10(-7) % of the wet weight. The structure of cribrostatin 3 (4a) was determined by results of high field (500 MHz) H-1 and C-13 NMR and HRMS interpretations. The same general approach to the structures of cribrostatins 4 (5) and 5 (4b) was completed by X-ray crystal structure determinations. Cribrostatins 3, 4, and 5 provided significant cancer cell line inhibitory activities. Cribrostatins 1 and 2(2) and the newly isolated cribrostatins 3-5 displayed antibacterial and/or antifungal activities. [References: 40]

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