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Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients

  1. Author:
    Radtke, Andrea J
    Postovalova, Ekaterina
    Varlamova, Arina
    Bagaev, Alexander
    Sorokina, Maria
    Kudryashova, Olga
    Meerson, Mark
    Polyakova, Margarita
    Galkin, Ilia
    Svekolkin, Viktor
    Isaev, Sergey
    Wiebe, Daniil
    Sharun, Anna
    Sarachakov, Alexander
    Perelman, Grigory
    Lozinsky, Yaroslav
    Yaniv, Ziv
    Lowekamp, Bradley C
    Speranza, Emily
    Yao, Li
    Pittaluga, Stefania
    Shaffer, Arthur L
    Jonigk, Danny
    Phelan, James D
    Davies-Hill, Theresa
    Huang, Da Wei
    Ovcharov, Pavel
    Nomie, Krystle
    Nuzhdina, Ekaterina
    Kotlov, Nikita
    Ataullakhanov, Ravshan
    Fowler, Nathan
    Kelly,Michael
    Muppidi, Jagan
    Davis, Jeremy L
    Hernandez, Jonathan M
    Wilson, Wyndham H
    Jaffe, Elaine S
    Staudt, Louis M
    Roschewski, Mark
    Germain, Ronald N

  2. Author Address

    Lymphocyte Biology Section and Center for Advanced Tissue Imaging, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA. Electronic address: andrea.radtke@nih.gov., BostonGene, Waltham, MA 02453, USA., Bioinformatics and Computational Bioscience Branch, NIAID, NIH, Bethesda, MD 20892, USA., Lymphocyte Biology Section and Center for Advanced Tissue Imaging, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA; Florida Research and Innovation Center, Cleveland Clinic Lerner Research Institute, Port Saint Lucie, FL 34987, USA., Li Yao Visuals, Rockville, MD 20855, USA., Laboratory of Pathology, NCI, NIH, Bethesda, MD 20892, USA., Lymphoid Malignancies Branch, NCI, NIH, Bethesda, MD 20892, USA; Tumor Targeted Delivery, Heme Malignancy Target Discovery Group, AstraZeneca, Gaithersburg, MD 20878, USA., Institute of Pathology, Aachen Medical University, RWTH Aachen, 52074 Aachen, Germany; German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), 30625 Hannover, Germany., Lymphoid Malignancies Branch, NCI, NIH, Bethesda, MD 20892, USA., CCR Single Analysis Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA., Surgical Oncology Program, Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.,
    1. Year: 2024
    2. Date: Feb 21
    3. Epub Date: 2024 02 21
  2. Journal: Cancer Cell
    1. 42
  4. Type of Article: Article
  1. Abstract:

    Follicular lymphoma (FL) is a generally incurable malignancy that evolves from developmentally blocked germinal center (GC) B cells. To promote survival and immune escape, tumor B cells undergo significant genetic changes and extensively remodel the lymphoid microenvironment. Dynamic interactions between tumor B cells and the tumor microenvironment (TME) are hypothesized to contribute to the broad spectrum of clinical behaviors observed among FL patients. Despite the urgent need, existing clinical tools do not reliably predict disease behavior. Using a multi-modal strategy, we examined cell-intrinsic and -extrinsic factors governing progression and therapeutic outcomes in FL patients enrolled onto a prospective clinical trial. By leveraging the strengths of each platform, we identify several tumor-specific features and microenvironmental patterns enriched in individuals who experience early relapse, the most high-risk FL patients. These features include stromal desmoplasia and changes to the follicular growth pattern present 20 months before first progression and first relapse. Published by Elsevier Inc.

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External Sources

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  2. DOI: 10.1016/j.ccell.2024.02.001
  3. PMID: 38428410
  4. PII : S1535-6108(24)00045-X

Library Notes

  1. Fiscal Year: FY2023-2024
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