Neolignan and 3-Benzylchroman Derivatives From Celastrus orbiculatus Thunb

Author:

Hua, Silu

Liu, Ping

Miao, Li

Zhang, Likui

Wang, Haibo

Liu, Yanqing

Wang,Dongdong

Jiang, Wei [ORCID]
Author Address

Marine Science & Technology Institute, College of Environmental Science & Engineering, Yangzhou University, Yangzhou, P. R. China., Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, P. R. China., Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, USA.,

Abstract:

Phytochemical investigation of the ethyl acetate extract of the stems of Celastrus orbiculatus Thunb. led to the isolation of a new neolignan, celastorbiol A (1), and two new homoisoflavones, celastrones A and B (2 and 3), along with five known 3-benzylchroman derivatives, including 7,4'-dihydrohomoisoflavanone (4), 3-deoxysappanone B (5), 3'-deoxysappanone A (6), bonducelin (7), and sappanone A (8). Their structures were determined based on extensive spectroscopic and spectrometric data analyses, and computational studies. Compounds 1, 6, and 8 exhibited cytotoxic activities against human gastric cancer AGS and HGC-27 cell lines with IC50 values that ranged from 42.82 ± 0.98 to 98.04 ± 1.33 µM. © 2025 Wiley-VHCA AG, Zurich, Switzerland.

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