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Characterization of the mouse JAB1 cDNA and protein

  1. Author:
    Bounpheng, M. A.
    Melnikova, I. N.
    Dodds, S. G.
    Chen, H. P.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Christy, B. A.

  2. Author Address

    Christy BA Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol San Antonio, TX 78245 USA Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol San Antonio, TX 78245 USA Univ Texas, Hlth Sci Ctr, Inst Biotechnol, Dept Mol Med San Antonio, TX 78245 USA NCI, Frederick Canc Res & Dev Ctr, Mammalian Genet Lab, ABL Basic Res Program Frederick, MD 21702 USA
    1. Year: 2000
  2. Journal: Gene
    1. 242
    2. 1-2
    3. Pages: 41-50
  4. Type of Article: Article
  1. Abstract:

    JAB1 was originally described as a transcriptional coactivator of c-Jun and Jun D. Recent data suggests that JAB1 is a component of a large protein complex, the JAB1 signalosome in mammals and the COP9 complex in plants. The JAB1 signalosome is implicated in the phosphorylation of selected transcription factors, while the COP9 complex is involved in repression of photomorphogenesis in Arabidopsis. In this study, we describe the partial characterization of mouse JAB1 (mJAB1). The murine JAB1 protein is encoded by a gene located on mouse chromosome 1. mJAB1 mRNA is abundantly expressed in a variety of adult tissues as well as in mouse embryos. The JAB1 protein was readily detectable in many cell types and localized to both the nucleus and cytoplasm. Endogenous JAB1 protein is relatively stable and its degradation is not perturbed by blocking 26S proteasome activity, suggesting that this protein is not degraded by the ubiquitin-mediated proteolytic pathway. (C) 2000 Elsevier Science B.V. All rights reserved. [References: 31]

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