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Comparative genomics of the eukaryotes

  1. Author:
    Rubin, G. M.
    Yandell, M. D.
    Wortman, J. R.
    Miklos, G. L. G.
    Nelson, C. R.
    Hariharan, I. K.
    Fortini, M. E.
    Li, P. W.
    Apweiler, R.
    Fleischmann, W.
    Cherry, J. M.
    Henikoff, S.
    Skupski, M. P.
    Misra, S.
    Ashburner, M.
    Birney, E.
    Boguski, M. S.
    Brody, T.
    Brokstein, P.
    Celniker, S. E.
    Chervitz, S. A.
    Coates, D.
    Cravchik, A.
    Gabrielian, A.
    Galle, R. F.
    et al.

  2. Author Address

    Rubin GM Univ Calif Berkeley, Howard Hughes Med Inst Berkeley, CA 94720 USA Univ Calif Berkeley, Howard Hughes Med Inst Berkeley, CA 94720 USA Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley Drosophila Genome Project Berkeley, CA 94720 USA Celera Genom Rockville, MD 20850 USA Genetixxpress Sydney NSW 2108 Australia Massachusetts Gen Hosp, Ctr Canc Charlestown, MA 02129 USA Univ Penn, Sch Med, Dept Genet Philadelphia, PA 19104 USA EMBL, EBI Cambridge CB10 1SD England Stanford Univ, Dept Genet Stanford, CA 94305 USA Fred Hutchinson Canc Res Ctr, Howard Hughes Med Inst Seattle, WA 98109 USA Natl Lib Med, Natl Ctr Biotechnol Informat, NIH Bethesda, MD 20894 USA NINDS, Neurogenet Unit, Neurochem Lab, NIH Bethesda, MD 20892 USA Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley Drosophila Genome Project Berkeley, CA 94720 USA Neomorphic Berkeley, CA 94710 USA Univ Leeds, Sch Biol Leeds LS2 9JT W Yorkshire England Harvard Univ, Dept Mol & Cellular Biol Cambridge, MA 02138 USA Univ Calif San Diego, Howard Hughes Med Inst, Dept Cellular & Mol Med La Jolla, CA 92093 USA Univ Calif San Diego, Howard Hughes Med Inst, Dept Pharmacol La Jolla, CA 92093 USA CALTECH, Div Biol Pasadena, CA 91125 USA MIT, Howard Hughes Med Inst Cambridge, MA 02139 USA BC Canc Res Ctr, Genome Sequence Ctr Vancouver BC V52 4E6 Canada Univ Maryland, Cell & Mol Biol Program Baltimore, MD 21201 USA CNRS, Ctr Genet Mol F-91198 Gif Sur Yvette France MIT, Ctr Learning & Memory Cambridge, MA 02139 USA NCI, Regulat Cell Growth Lab, Div Basic Sci, Frederick Canc Res & Dev Ctr,NIH Ft Detrick, MD 21702 USA et al
    1. Year: 2000
  2. Journal: Science
    1. 287
    2. 5461
    3. Pages: 2204-2215
  4. Type of Article: Review
  1. Abstract:

    A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease. [References: 84]

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