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Distribution and Localization of a Novel Cholecystokinin-Releasing Factor in the Rat Gastrointestinal Tract

  1. Author:
    Tarasova, N.
    Spannagel, A. W.
    Green, G. M.
    Gomez, G.
    Reed, J. T.
    Thompson, J. C.
    Hellmich, M. R.
    Reeve, J. R.
    Liddle, R. A.
    Greeley, G. H.

  2. Author Address

    Greeley GH UNIV TEXAS MED BRANCH DEPT SURG GALVESTON, TX 77555 USA UNIV TEXAS MED BRANCH DEPT SURG GALVESTON, TX 77555 USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM FREDERICK, MD 21702 USA UNIV TEXAS HLTH SCI CTR DEPT PHYSIOL SAN ANTONIO, TX 78284 USA VET ADM W LOS ANGELES CTR ULCER RES & EDUC LOS ANGELES, CA 90073 USA VET ADM W LOS ANGELES DIGEST DIS RES CTR LOS ANGELES, CA 90073 USA DUKE UNIV MED CTR DEPT MED DURHAM, NC 27710 USA
    1. Year: 1997
  2. Journal: Endocrinology
    1. 138
    2. 12
    3. Pages: 5550-5554
  4. Type of Article: Article
  1. Abstract:

    The purpose of this study was to examine the distribution and localization of an intestinal cholecystokinin (CCK)-releasing factor, called luminal CCK-releasing factor (LCRF), in the gastrointestinal tract and pancreas of the rat. RIA analysis indicates that LCRF immunoreactivity is found throughout the gut including the pancreas, stomach, duodenum, jejunum, ileum, and colon with the highest levels in the small intestine. Immunohistochemistry analysis shows LCRF immunoreactivity Staining in intestinal villi, Brunner's glands of the duodenum, the duodenal myenteric plexus, gastric pits, pancreatic ductules, and pancreatic islets. These results indicate potential sources for secretagogue-stimulated release of luminal LCRF and support the hypothesis that LCRF is secreted into the intestinal lumen to stimulate CCK release from mucosal CCK cells. [References: 23]

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