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Localization of the Drosophila MAGUK protein Polychaetoid is controlled by alternative splicing

  1. Author:
    Wei, X. R.
    Ellis, H. M.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, Mol Control & Genet Sect, Bldg 539, Room 243, POB B, Frederick, MD 21702 USA. Emory Univ, Dept Biol, Atlanta, GA 30322 USA. Emory Univ, Grad Program Biochem Cell & Dev Biol, Atlanta, GA 30322 USA. Ellis HM NCI, Frederick Canc Res & Dev Ctr, Mol Control & Genet Sect, Bldg 539, Room 243, POB B, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Mechanisms of Development
    1. 100
    2. 2
    3. Pages: 217-231
  4. Type of Article: Article
  1. Abstract:

    The Drosophila membrane-associated guanylate kinase (MAGUK) protein Polychaetoid (Pyd) is required for dorsal closure of the embryo, sensory organ patterning, and cell fate specification in the developing eye. We demonstrate that pyd is alternatively spliced resulting in two isoforms that differ by the presence or absence of exon 6. To determine the role of alternative splicing in Pyd function, we generated antibodies specific for each isoform. We find that the exon 6(+) form of Pyd is localized at adherens junctions of embryonic and imaginal epithelia, while the exon 6(-) form is distributed broadly along the lateral membrane. These results suggest that localization of Pyd is controlled by alternative splicing and raise the possibility that exon 6 represents a distinct protein-protein interaction domain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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