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Influence of antioxidants and the CYP1A1 isoleucine to valine polymorphism on the Smoking Lung Cancer Association

  1. Author:
    Ratnasinghe, D.
    Tangrea, J. A.
    Stewart, C.
    Bhat, N. K.
    Virtamo, J.
    Albanes, D.
    Taylor, P. R.

  2. Author Address

    NCI, Div Clin Sci, Canc Prevent Studies Branch, NIH, Suite 321, 6006 Execut Blvd, MSC 7058, Bethesda, MD 20892 USA. NCI, Div Clin Sci, Canc Prevent Studies Branch, NIH, Bethesda, MD 20892 USA. FCRDC, SAIC, Frederick, MD USA. Natl Publ Hlth Inst, Helsinki, Finland.
    1. Year: 2001
  2. Journal: Anticancer Research
    1. 21
    2. 2B
    3. Pages: 1295-1299
  4. Type of Article: Article
  1. Abstract:

    To evaluate the association between CYP1A1 genotype and king cancer risk and to assess the effect of CYP1A1 genotype and antioxidant supplementation on the smoking - lung cancer relationship we conducted a case-control study nested within a large cancel prevention trial cohort. Controls (n=324) were matched to cases (n=282) on age (+/- 5 years), intervention group and study clinic in a 1:1 ratio using incidence density sampling. Genotype was determined by a PCR-based method and logistic regression was used to calculate relative risk estimates. Overall, we found no association between CYP1A1 genotype and lung cancer risk. CYP1A1 genotype did not modify the effect of smoking on lung cancel risk. However; in an examination of subgroups defined by randomized intervention assignment our findings suggest that alpha-tocopherol supplementation may reduce the risk of lung cancer associated with cumulative smoking exposure regardless of CYP1A1 genotype with the greatest effect seen among those with the variant CYP1A1 allele.

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