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Molecular cloning of mouse collectin liver 1

  1. Author:
    Kawai, T.
    Suzuki, Y.
    Eda, S.
    Kase, T.
    Ohtani, K.
    Sakai, Y.
    Keshi, H.
    Fukuoh, A.
    Sakamoto, T.
    Nozaki, M.
    Copeland, N. G.
    Jenkins, N. A.
    Wakamiya, N.

  2. Author Address

    Osaka Prefectural Inst Publ Hlth, Div Food Microbiol, Nagashinari Ku, 1-3-69 Nakamichi, Osaka 5370025, Japan Osaka Prefectural Inst Publ Hlth, Div Food Microbiol, Nagashinari Ku, Osaka 5370025, Japan Osaka Prefectural Inst Publ Hlth, Div Pathol, Nagashinari Ku, Osaka 5370025, Japan Osaka Prefectural Inst Publ Hlth, Div Virol, Nagashinari Ku, Osaka 5370025, Japan Fuso Pharmaceut Ind Ltd, Ctr Res & Dev, Dept Biol Sci Res, Joto Ku, Osaka 5360025, Japan Asahikawa Med Coll, Dept Microbiol, Asahikawa, Hokkaido 0788510, Japan Osaka Univ, Res Inst Microbial Dis, Dept Sci, Lab Anim Expt, Suita, Osaka 5650871, Japan Natl Canc Inst Frederick, Mouse Canc Genet Program, Frederick, MD 21702 USA Kawai T Osaka Prefectural Inst Publ Hlth, Div Food Microbiol, Nagashinari Ku, 1-3-69 Nakamichi, Osaka 5370025, Japan
    1. Year: 2002
  2. Journal: Bioscience Biotechnology and Biochemistry
    1. 66
    2. 10
    3. Pages: 2134-2145
  4. Type of Article: Article
  1. Abstract:

    Collectins are members of the superfamily of vertebrate C-type lectins that contain a collagen-like region, and are involved in first-line host defense. We earlier cloned and characterized a new kind of collectin, collectin liver 1 (CL-L1). In this study, we isolated the mouse homologue of CL-L1 encoding 277 amino acid residues; its deduced protein sequence was 88% identical with human CL-L1. Mouse CL-L1 mRNA was expressed mainly in the liver and stomach, but was found also in muscles, testes, intestines, and embryos. In mouse embryos, the level of CL-L1 mRNA gradually increased with embryonic age. In 16-day- old mouse embryos, CL-L1 mRNA was expressed in the liver, amnion, and visceral yolk sac. The mouse CL-L1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q. CL-L1 was a highly conserved protein in mammals, birds, and fish.

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