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Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2

  1. Author:
    Biragyn, A.
    Ruffini, P. A.
    Leifer, C. A.
    Klyushnenkova, E.
    Shakhov, A.
    Chertov, O.
    Shirakawa, A. K.
    Farber, J. M.
    Segal, D. M.
    Oppenheim, J. J.
    Kwak, L. W.

  2. Author Address

    NCI, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA NCI, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA NCI, Expt Immunol Branch, Bethesda, MD 20892 USA Sci Applicat Int Corp, Intramural Res Support Program, Frederick, MD 21702 USA Sci Applicat Int Corp, Prot Chem Lab, Frederick, MD 21702 USA NIAID, Clin Invest Lab, NIH, Bethesda, MD 20892 USA NCI, Mol Immunoregulat Lab, Frederick, MD 21702 USA Biragyn A NCI, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA
    1. Year: 2002
  2. Journal: Science
    1. 298
    2. 5595
    3. Pages: 1025-1029
  4. Type of Article: Article
  1. Abstract:

    beta-Defensins are small antimicrobial peptides of the innate immune system produced in response to microbial infection of mucosal tissue and skin. We demonstrate that murine beta- defensin 2 (mDF2beta) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and dendritic cell maturation. These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens.

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