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Isolation and Characterization of New Anti-Hiv and Cytotoxic Leads From Plants, Marine, and Microbial Organisms

  1. Author:
    McKee, T. C.
    Bokesch, H. R.
    McCormick, J. L.
    Rashid, M. A.
    Spielvogel, D.
    Gustafson, K. R.
    Alavanja, M. M.
    Cardellina, J. H.
    Boyd, M. R.

  2. Author Address

    Mckee TC NCI LAB DRUG DISCOVERY RES & DEV DEV THERAPEUT PROGRAM DIV CANC TREATMENT DIAG & CTR FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Journal of Natural Products
    1. 60
    2. 5
    3. Pages: 431-438
  4. Type of Article: Article
  1. Abstract:

    New cytotoxic isomalabaricane triterpenes have been isolated from a sponge Stelletta sp. (1-7); anti-HIV pterocarpans (8 and 9) and isoflavanoids (12-16 and 18) were elucidated from two tropical plants in the genus Erythrina; and anti-HIV enniatins (20 and 22-23) were characterized from fungi in the genera Fusarium and Alternaria. The enniatins were evaluated for in vivo anti-HIV activity in the hollow fiber assay. [References: 39]

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