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Cutting edge: Expansion of the KIR locus by unequal crossing over

  1. Author:
    Martin, M. P.
    Bashirova, A.
    Traherne, J.
    Trowsdale, J.
    Carrington, M.

  2. Author Address

    NCI, Basic Res Program, Sci Applicat Int Corp, POB B, Frederick, MD 21702 USA NCI, Basic Res Program, Sci Applicat Int Corp, Frederick, MD 21702 USA NCI, Lab Genom Divers, Frederick, MD 21702 USA Univ Cambridge, Dept Pathol, Div Immunol, Cambridge CB2 1QP, England Carrington M NCI, Basic Res Program, Sci Applicat Int Corp, POB B, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Journal of Immunology
    1. 171
    2. 5
    3. Pages: 2192-2195
  4. Type of Article: Article
  1. Abstract:

    The killer Ig-like receptor (KIR) genes have high sequence similarity and are organized in a head-to-tail fashion. These properties may enhance misalignment of homologous chromosomes during synapsis preceding meiotic recombination, resulting in unequal crossing over. We have identified an extended KIR haplotype that contains a novel hybrid gene and two copies of each of two previously described KIR genes. A parsimonious mechanism for the derivation of this haplotype invokes unequal crossing over between two known ancestral KIR haplotypes. These data raise the possibility that unequal crossing over may be responsible in part for the expansion/contraction of KIR haplotypes as well as other homologous gene families that map in tandem.

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