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Recent advances in the synthesis of confortnationally locked nucleosides and their success in probing the critical question of conformational preferences by their biological targets

  1. Author:
    Choi, Y.
    Moon, H. R.
    Yoshimura, V.
    Marquez, V. E.

  2. Author Address

    NCI, Med Chem Lab, Ctr Canc Res, NIH,HHS, 376 Boyles St, Frederick, MD 21702 USA NCI, Med Chem Lab, Ctr Canc Res, NIH,HHS, Frederick, MD 21702 USA Marquez VE NCI, Med Chem Lab, Ctr Canc Res, NIH,HHS, 376 Boyles St, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Nucleosides Nucleotides & Nucleic Acids
    1. 22
    2. 5-8
    3. Pages: 547-557
  4. Type of Article: Article
  1. Abstract:

    The present work describes some recent approaches to the syntheses of three classes of locked-North nucleosides: beta-D- ribo-, beta-D-deoxyribo-, and beta-D-dideoxy-ribonucleosides. The method developed for the latter class permitted access to a novel bicyclo[3.1.0]hexene-type nucleosides structurally similar to D4T and carbovir. A structural analysis and biological activities are discussed.

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