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A new cytotoxic and tubulin-interactive milnamide derivative from a marine sponge Cymbastela sp

  1. Author:
    Chevallier, C.
    Richardson, A. D.
    Edler, M. C.
    Hamel, E.
    Harper, M. K.
    Irel, C. M.

  2. Author Address

    Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA NCI, Div Canc Treatment & Diagnosis, Dev Therapeut Program, Screening Technol Branch,NIH, Ft Detrick, MD 21702 USA Ireland CM Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA
    1. Year: 2003
  2. Journal: Organic Letters
    1. 5
    2. 20
    3. Pages: 3737-3739
  4. Type of Article: Article
  1. Abstract:

    The crude methanol extract of a marine sponge Cymbastela sp. collected in Papua New Guinea was selected for chemical investigation due to its significant cytotoxicity. Fractionation of the extract led to the isolation of jaspamide (1), hemiasterlin (2), milnamide A (3), and a new metabolite, milnamide D (4). The structure was solved by interpretation of NMR and mass spectra data. The cytotoxic and antitubulin activities of milinamide D (4) were evaluated.

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